Patent US4191753A successfully refreshed from Google Patents.
US4191753A
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Anti-hypertensive peptide analogs
Assignee: University of Miami
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Filing: 1978-11-06
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Granted: 1980-03-04
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Expires: 1998-11-06
Abstract
Abstract Novel peptides having the sequence <Glu-Trp-A.sub.3 -Arg-A.sub.5 -Gln-Ile-A.sub.8 -A.sub.9 wherein A 3 , A 5 , A 8 and A 9 are either L-proline or L-3,4-dehydroproline, are disclosed. These peptides are potent inhibitors of angiotensin converting enzyme and are useful as antihypertensive agents.
Inventors
- 👤 James W. Ryan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 13:31
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
66 words
A peptide comprising the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, at least one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L configuration.
Claim 2
Dependent Claim
66 words
A peptide comprising the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, at least one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L configuration.
Claim 3
Dependent Claim
21 words
The peptide of claim 1 wherein A 3 is L-3,4-dehydroproline and A 5 , A 8 and A 9 are L-proline.
Claim 4
Dependent Claim
21 words
The peptide of claim 1 wherein A 5 is L-3,4-dehydroproline and A 3 , A 8 and A 9 are L-proline.
Claim 5
Dependent Claim
21 words
The peptide of claim 1 wherein A 9 is L-3,4-dehydroproline and A 3 , A 5 and A 8 are L-proline.
Claim 6
Dependent Claim
66 words
A peptide comprising the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, not more than one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 7
Dependent Claim
66 words
A peptide comprising the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, not more than one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 8
Independent Claim
88 words
A method for inhibiting angiotensin converting enzyme in vivo comprising administering an effective dose of an inhibiting peptide selected from the group consisting of peptides comprising the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, at least one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 9
Independent Claim
88 words
A method for inhibiting angiotensin converting enzyme in vivo comprising administering an effective dose of an inhibiting peptide selected from the group consisting of peptides comprising the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, at least one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 10
Dependent Claim
15 words
The method of claim 6 wherein the inhibiting peptide is ΔPro 3 -BPP 9a .
Claim 11
Dependent Claim
15 words
The method of claim 6 wherein the inhibiting peptide is ΔPro 5 -BPP 9a .
Claim 12
Dependent Claim
15 words
The method of claim 6 wherein the inhibiting peptide is ΔPro 9 -BPP 9a .
Claim 13
Independent Claim
92 words
A method for inhibiting angiotensin converting enzyme in vivo comprising administering an effective dose of an inhibiting peptide selected from the group consisting of peptides comprising the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L 3 ,4 -dehydroproline, not more than one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 14
Independent Claim
92 words
A method for inhibiting angiotensin converting enzyme in vivo comprising administering an effective dose of an inhibiting peptide selected from the group consisting of peptides comprising the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L 3 ,4 -dehydroproline, not more than one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 15
Independent Claim
86 words
A method for lowering blood pressure in vivo comprising administering an effective dose of a peptide selected from the group consisting of peptides having the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, at least one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 16
Independent Claim
86 words
A method for lowering blood pressure in vivo comprising administering an effective dose of a peptide selected from the group consisting of peptides having the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, at least one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 17
Dependent Claim
15 words
The method of claim 11 wherein the inhibiting peptide is ΔPro 3 -BPP 9a .
Claim 18
Dependent Claim
15 words
The method of claim 11 wherein the inhibiting peptide is ΔPro 5 -BPP 9a .
Claim 19
Dependent Claim
15 words
The method of claim 11 wherein the inhibiting peptide is ΔPro 9 -BPP 9a .
Claim 20
Independent Claim
87 words
A method for lowering blood pressure in vivo comprising administering an effective dose of a peptide selected from the group consisting of peptides having the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, not more than one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
Claim 21
Independent Claim
87 words
A method for lowering blood pressure in vivo comprising administering an effective dose of a peptide selected from the group consisting of peptides having the amino acid sequence <Glu-Trp-A 3 -Arg-A 5 -Gln-Ile-A 8 -A 9 wherein: A 3 is L-Proline or L-3,4-dehydroproline, A 5 is L-Proline or L-3,4-dehydroproline, A 8 is L-Proline or L-3,4-dehydroproline, A 9 is L-Proline or L-3,4-dehydroproline, not more than one of A 3 , A 5 , A 8 and A 9 is L-3,4-dehydroproline and all amino acids are in the L-configuration.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-04 | 1983-09-03 | 1984-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-04 | 1987-09-03 | 1988-03-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-04 | 1991-09-03 | 1992-03-04 | $7700.00 | Window Closed / Lapsed |