US4190648A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Peptides having somatostatin activity
Assignee: Merck and Co Inc
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Filing: 1979-03-13
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Granted: 1980-02-26
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Expires: 1999-03-13
Abstract
Abstract Peptides having the structural formula: <IMAGE> +TR <IMAGE> and <IMAGE> +TR <IMAGE> wherein A is D-Thr, D-Val; B is D-Phe, D-Tyr; C is D-Phe, D-Tyr, O-Me-D-Tyr; wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, inhibiting growth hormone release and inhibiting glucagon release in humans and animals without materially affecting gastric secretion. They have a longer duration of action than somatostatin.
Inventors
- 👤 Daniel F. Veber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 06:00
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; A; A61; A61P; A61P1/00; A61P1/04; A61P5/00; A61P5/02; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
38 words
Compounds of the formula: ##STR10## wherein A is D--Thr, D--Val; B is D--Phe, D--Tyr; C is D--Phe, D--Tyr, O--Me--D--Tyr; wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof.
Claim 2
Dependent Claim
38 words
Compounds of the formula: ##STR10## wherein A is D--Thr, D--Val; B is D--Phe, D--Tyr; C is D--Phe, D--Tyr, O--Me--D--Tyr; wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof.
Claim 3
Dependent Claim
19 words
The compounds according to claim 1 having the formula: ##STR11## and the pharmaceutically acceptable non-toxic acid addition salts thereof.
Claim 4
Dependent Claim
52 words
A composition comprising a therapeutically effective amount of the peptides having the structure: ##STR12## wherein A is D--Thr, D--Val, B is D--Phe, D--Tyr, C is D--Phe, D--Tyr, O--Me--D--Tyr wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof in a pharmaceutically acceptable excipient.
Claim 5
Dependent Claim
52 words
A composition comprising a therapeutically effective amount of the peptides having the structure: ##STR12## wherein A is D--Thr, D--Val, B is D--Phe, D--Tyr, C is D--Phe, D--Tyr, O--Me--D--Tyr wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof in a pharmaceutically acceptable excipient.
References Cited (Backward Citations)
US4146612A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-25 | 1983-08-27 | 1984-02-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-25 | 1987-08-27 | 1988-02-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-25 | 1991-08-27 | 1992-02-26 | $7700.00 | Window Closed / Lapsed |