US4190542A — Disposable column

Claim 1

Independent Claim 223 words

Disposable haemoperfusion equipment comprising: (A) a column, (i) formed in biocompatible synthetic polymer material, (ii) having a smooth internal surface, (iii) enclosing perforate internal support means towards each end of said column (iv) diminishing in diameter from a maximum diameter intermediate said ends, and then (v) converging smoothly at each end of said column to an inlet port and an outlet port respectively, each such port defining a minimal dead space between itself and the nearer support means, (vi) said column having a length to maximum diameter ratio of 1.5:1 to 5:1 and an internal volume of 50 to 800 ml., and (vii) said column being formed as two identical halves located end to end, each half possessing a first frusto-conical tapering portion having an included angle of from 10° to 30°, and a second frusto-conical tapering portion, integral with said first portion, but of an included angle of from 50° to 70°, tapering to a liquid flow connection at each end of said column; (B) a body of absorbtive particulate material, (i) substantially filling the column and held between the support means so that the particles do not move relatively in use, and (ii) consisting of particles having a smooth biocompatible surface; and (C) a biocompatible liquid charge filling the column, chosen from the group of degassed isotonic saline and plasma extender.

Claim 2

Dependent Claim 223 words

Disposable haemoperfusion equipment comprising: (A) a column, (i) formed in biocompatible synthetic polymer material, (ii) having a smooth internal surface, (iii) enclosing perforate internal support means towards each end of said column (iv) diminishing in diameter from a maximum diameter intermediate said ends, and then (v) converging smoothly at each end of said column to an inlet port and an outlet port respectively, each such port defining a minimal dead space between itself and the nearer support means, (vi) said column having a length to maximum diameter ratio of 1.5:1 to 5:1 and an internal volume of 50 to 800 ml., and (vii) said column being formed as two identical halves located end to end, each half possessing a first frusto-conical tapering portion having an included angle of from 10° to 30°, and a second frusto-conical tapering portion, integral with said first portion, but of an included angle of from 50° to 70°, tapering to a liquid flow connection at each end of said column; (B) a body of absorbtive particulate material, (i) substantially filling the column and held between the support means so that the particles do not move relatively in use, and (ii) consisting of particles having a smooth biocompatible surface; and (C) a biocompatible liquid charge filling the column, chosen from the group of degassed isotonic saline and plasma extender.

Claim 3

Dependent Claim 15 words

Haemoperfusion equipment as claimed in claim 1 of internal volume from 600 to 800 ml.

Claim 4

Dependent Claim 16 words

Haemoperfusion equipment as claimed in claim 1, having an internal volume from 50 to 400 ml.

Claim 5

Dependent Claim 31 words

Haemoperfusion equipment as claimed in claim 1, wherein the included angle of the first portion is from 17° to 22° and that of the second portion is from 60° to 65°.

Claim 6

Dependent Claim 22 words

Haemoperfusion equipment as claimed in claim 1 wherein the column has a funnel-shaped connecting piece at each end defining the dead space.

Claim 7

Dependent Claim 27 words

Haemoperfusion equipment as claimed in claim 5, wherein the dead space is closed by a support grid fixed across the broader end of the funnel-shaped connecting piece.

Claim 8

Dependent Claim 24 words

Haemoperfusion equipment as claimed in claim 6, wherein the ratio of grid diameter to length of the converging portion ranges from 0.5:1 to 2:1.

Claim 9

Dependent Claim 47 words

Haemoperfusion equipment as claimed in claim 1, wherein the absorbent is a particulate absorptive carbon the particles of which are provided with a protective layer of a biocompatible polymer resistant to mechanical breakdown and providing a smooth permeable particle surface without plugging the pores of the material.

Claim 10

Dependent Claim 25 words

Haemoperfusion equipment as claimed in claim 8 wherein the biocompatible coating polymer is poly(hydroxyethylmethacrylate) in an amount of 0.25 to 5% w/w of the carbon.

Claim 11

Dependent Claim 171 words

Disposable haemoperfusion equipment, comprising: (A) a column, the internal shape of which is that of a trochoid of revolution, (i) formed in biocompatible synthetic polymer material, (ii) having a smooth internal surface, (iii) enclosing perforate internal support means towards each end of the column, (iv) diminishing in diameter from a maximum diameter intermediate said ends, and then (v) converging smoothly at each end of said column to an inlet port and an outlet port respectively, each such port defining a minimal dead space between itself and the nearer support means, (vi) said column having a length to maximum diameter ratio of 1.5:1 to 5:1 and an internal volume of 50 to 800 ml; (B) a body of absorbtive particulate material, (i) substantially filling the column and held between the support means so that the particles do not move relatively in use, and (ii) consisting of particles having a smooth biocompatible surface; and (C) a biocompatible liquid charge filling the column, chosen from the group of degassed isotonic saline and plasma extender.

Claim 12

Dependent Claim 171 words

Disposable haemoperfusion equipment, comprising: (A) a column, the internal shape of which is that of a trochoid of revolution, (i) formed in biocompatible synthetic polymer material, (ii) having a smooth internal surface, (iii) enclosing perforate internal support means towards each end of the column, (iv) diminishing in diameter from a maximum diameter intermediate said ends, and then (v) converging smoothly at each end of said column to an inlet port and an outlet port respectively, each such port defining a minimal dead space between itself and the nearer support means, (vi) said column having a length to maximum diameter ratio of 1.5:1 to 5:1 and an internal volume of 50 to 800 ml; (B) a body of absorbtive particulate material, (i) substantially filling the column and held between the support means so that the particles do not move relatively in use, and (ii) consisting of particles having a smooth biocompatible surface; and (C) a biocompatible liquid charge filling the column, chosen from the group of degassed isotonic saline and plasma extender.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1983-02-25	1983-08-27	1984-02-26	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1987-02-25	1987-08-27	1988-02-26	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1991-02-25	1991-08-27	1992-02-26	$7700.00	Window Closed / Lapsed

Disposable column

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