US4186192A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilized immune serum globulin
Assignee: Bayer Corp
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Filing: 1978-12-18
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Granted: 1980-01-29
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Expires: 1998-12-18
Abstract
Abstract Composition comprising an aqueous solution of immune serum globulin and maltose, the amount of maltose being sufficient to inhibit "shedding" of the globulin with time.
Inventors
- 👤 John L. Lundblad
- 👤 Willis L. Warner
- 👤 Peter M. Fernandes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 04:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K39/00; A61K39/395; A61K39/39591; A61K47/00; A61K47/06; A61K47/26
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
38 words
A stabilized immune serum globulin preparation comprising an aqueous solution of a therapeutically effective amount of molecules of ISG and maltose, the amount of maltose being sufficient to inhibit shedding of the globulin over prolonged periods of time.
Claim 2
Dependent Claim
38 words
A stabilized immune serum globulin preparation comprising an aqueous solution of a therapeutically effective amount of molecules of ISG and maltose, the amount of maltose being sufficient to inhibit shedding of the globulin over prolonged periods of time.
Claim 3
Dependent Claim
19 words
The preparation of claim 1 wherein the amount of maltose ranges from about 2.5 to about 18 weight percent.
Claim 4
Dependent Claim
19 words
The preparation of claim 2 wherein the amount of maltose ranges from about 5 to about 15 weight percent.
Claim 5
Dependent Claim
15 words
The preparation of claim 3 wherein the amount of maltose is about 10 weight percent.
Claim 6
Dependent Claim
10 words
The preparation of claim 1 wherein the solution includes glycine.
Claim 7
Dependent Claim
17 words
The preparation of claim 5 wherein the glycine is present in a concentration of about 0.1 M.
Claim 8
Dependent Claim
22 words
The preparation of claim 1 wherein the globulin present is IMGG, and the amount of the globulin is about 16.5 wt. %.
Claim 9
Dependent Claim
21 words
The preparation of claim 1 wherein the globulin is IVGG, and the amount of the globulin is about 5 wt. %.
Claim 10
Dependent Claim
16 words
The preparation of claim 1 wherein amount of maltose is sufficient to assure pharmaceutically acceptable osmolality.
Claim 11
Dependent Claim
18 words
The preparation of claim 9 wherein the osmolality of the solution ranges from about 170 to 600 m0sm/kg.
Claim 12
Dependent Claim
14 words
The preparation of claim 10 wherein the osmolality is about 260 to 500 m0sm/kg.
Claim 13
Dependent Claim
42 words
A sterile, pharmaceutically acceptable preparation comprising an aqueous solution of molecules of an immune serum globulin, the globulin having been modified for intravenous administration, and maltose, the maltose being present in an amount sufficient to inhibit substantial shedding of the globulin molecules.
Claim 14
Dependent Claim
42 words
A sterile, pharmaceutically acceptable preparation comprising an aqueous solution of molecules of an immune serum globulin, the globulin having been modified for intravenous administration, and maltose, the maltose being present in an amount sufficient to inhibit substantial shedding of the globulin molecules.
Claim 15
Dependent Claim
17 words
The preparation of claim 12 wherein the amount of maltose is sufficient to inhibit visually detectable shedding.
Claim 16
Dependent Claim
19 words
The preparation of claim 12 wherein the amount of maltose ranges from about 2.5 to about 18 wt. %.
Claim 17
Dependent Claim
19 words
The preparation of claim 14 wherein the amount of maltose ranges from about 5 to about 15 wt. %.
Claim 18
Dependent Claim
15 words
The preparation of claim 15 wherein the amount of maltose is about 10 wt. %.
Claim 19
Dependent Claim
17 words
The preparation of claim 16 wherein the aqueous solution includes about 5 weight percent of the globulin.
Claim 20
Dependent Claim
10 words
The preparation of claim 12 wherein the solution includes glycine.
Claim 21
Dependent Claim
13 words
The preparation of claim 18 wherein the glycine concentration is about 0.1 M.
Claim 22
Dependent Claim
13 words
The preparation of claim 12 wherein the solution has a pharmaceutically acceptable osmolality.
References Cited (Backward Citations)
US4089944A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-28 | 1983-07-30 | 1984-01-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-28 | 1987-07-30 | 1988-01-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-28 | 1991-07-30 | 1992-01-29 | $7700.00 | Window Closed / Lapsed |