US4183962A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for oxygenating blood by the utilization of liquid membranes
Assignee: ExxonMobil Technology and Engineering Co
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Filing: 1978-01-16
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Granted: 1980-01-15
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Expires: 1998-01-16
Abstract
Abstract The instant invention relates to an improved process for oxygenating blood comprising: contacting said blood with oxygen-containing bubbles, said bubbles being coated with a liquid membrane, said liquid membrane phase permitting the permeation of oxygen into the blood whereby at least a portion of said oxygen passes through said membrane and into said blood; removing said liquid membrane coated bubbles as a three phase foam comprising gas bubbles coated with said liquid membrane suspended in blood; and coalescing said foam comprising gas bubbbles to form three separate bulk phases comprising the liquid membrane phase, a gaseous phase and a blood phase, wherein the improvement comprises a liquid membrane phase comprising a biologically non-retainable liquid halocarbon compound. These liquid membrane formulations having a membrane phase comprising a biologically non-retainable liquid halocarbon compound exhibit improved coalescing characteristics.
Inventors
- 👤 William J. Asher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 14:08
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K31/025; A61M; A61M1/00; A61M1/14; A61M1/16; A61M1/1698; A61M1/32; A61M1/322; B; B01; B01D; B01D61/00; B01D61/38; B01D61/40; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
153 words
An improved process for oxygenating blood comprising contacting said blood with gaseous oxygen-containing bubbles, said bubbles being coated with a liquid membrane, said liquid membrane permitting the permeation of oxygen into the blood whereby at least a portion of said oxygen passes through said membrane and into said blood; removing said liquid membrane coated bubbles as a three phase foam comprising gas bubbles coated with said liquid membrane suspended in blood; and coalescing said foam comprising gas bubbles to form three separate bulk phases comprising the liquid membrane phase, a gaseous phase and a blood phase, wherein the improvement comprises a liquid membrane phase comprising a biologically non-retainable C 6 -C 25 liquid per-halocarbon compound or a mixture of biologically non-retainable liquid per-halocarbon compounds, wherein at least 50% of any of said per-halocarbon which may be introduced into the treated animal by said process is eliminated from the treated animal after four months.
Claim 2
Dependent Claim
153 words
An improved process for oxygenating blood comprising contacting said blood with gaseous oxygen-containing bubbles, said bubbles being coated with a liquid membrane, said liquid membrane permitting the permeation of oxygen into the blood whereby at least a portion of said oxygen passes through said membrane and into said blood; removing said liquid membrane coated bubbles as a three phase foam comprising gas bubbles coated with said liquid membrane suspended in blood; and coalescing said foam comprising gas bubbles to form three separate bulk phases comprising the liquid membrane phase, a gaseous phase and a blood phase, wherein the improvement comprises a liquid membrane phase comprising a biologically non-retainable C 6 -C 25 liquid per-halocarbon compound or a mixture of biologically non-retainable liquid per-halocarbon compounds, wherein at least 50% of any of said per-halocarbon which may be introduced into the treated animal by said process is eliminated from the treated animal after four months.
Claim 3
Dependent Claim
27 words
The process of claim 1 wherein at least 75% of said per-halocarbon present after treatment of said blood is eliminated from the treated animal after two months.
Claim 4
Dependent Claim
16 words
The process of claim 1 wherein said liquid membrane comprises one biologically non-retainable liquid per-halocarbon compound.
Claim 5
Dependent Claim
23 words
The process of claim 2 wherein said per-halocarbon is substituted with a halogen selected from the group consisting of fluorine, chlorine and bromine.
Claim 6
Dependent Claim
22 words
The process of claim 2 wherein said per-halocarbon is substituted with a halogen selected from the group consisting of fluorine and bromine.
Claim 7
Dependent Claim
13 words
The process of claim 2 wherein said per-halocarbon is substituted solely with fluorine.
Claim 8
Dependent Claim
40 words
The process of claim 6 wherein said per-halocarbon compound is selected from the group consisting of straight chain, branched chain or cyclic halocarbons containing from 6 to 25 carbon atoms per molecule wherein each of said carbon atoms is saturated.
Claim 9
Dependent Claim
11 words
The process of claim 7 wherein said per-halocarbon compound is cyclic.
Claim 10
Dependent Claim
37 words
The process of claim 6 wherein said per-halocarbon compound is selected from the group consisting of straight chain, branched chain or cyclic halocarbons containing from 7 carbons to 15 carbons wherein each of said carbons is saturated.
Claim 11
Dependent Claim
11 words
The process of claim 9 wherein said per-halocarbon compound is cyclic.
Claim 12
Dependent Claim
37 words
The process of claim 6 wherein said per-halocarbon compound is selected from the group consisting of straight chain, branched chain or cyclic halocarbons containing from 8 carbons to 12 carbons wherein each of said carbons is saturated.
Claim 13
Dependent Claim
11 words
The process of claim 11 wherein said per-halocarbon compound is cyclic.
Claim 14
Dependent Claim
19 words
The process of claim 2 wherein said per-halocarbon is selected from the group consisting of perfluorooctylbromide, perfluorodecaline and perfluoromethyldecaline.
Claim 15
Dependent Claim
19 words
The process of claim 2 wherein said per-halocarbon compound is selected from the group consisting of perfluorodecaline and perfluoromethyldecaline.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-14 | 1983-07-16 | 1984-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-14 | 1987-07-16 | 1988-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-14 | 1991-07-16 | 1992-01-15 | $7700.00 | Window Closed / Lapsed |