5-Keto prostaglandin Fα analogs

Claim 1

A compound of the formula ##STR33## wherein R 20 is ##STR34## wherein L is (1) --(CH 2 )d-C(R 2 ) 2 -- (2) --O--CH 2 --Y-- or (3) --CH═CH-- wherein d is zero to 5, R 2 is hydrogen, methyl, or fluoro, being the same or different with the proviso that one R 2 is not methyl when the other is fluoro, and Y is a valence bond, --CH 2 --, or --(CH 2 ) 2 --, wherein Q is ##STR35## wherein R 8 is hydrogen or alkyl of one to 4 carbon atoms, inclusive, wherein R 3 is (a) hydrogen, (b) alkyl of one to 12 carbon atoms, inclusive, (c) cycloalkyl of 3 to 10 carbon atoms, inclusive, (d) aralkyl of 7 to 12 carbon atoms, inclusive, (e) phenyl, (f) phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, ##STR36## wherein R 10 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl, and wherein R 11 is hydrogen or benzoyl, or (n) a pharmacologically acceptable cation, wherein R 60 is ##STR37## wherein C g H 2 .sbsb.g is alkylene of one to 9 carbon atoms, inclusive, with one to 5 carbon atoms, inclusive, in the chain between --CR 5 R 6 -- and terminal methyl, wherein R 5 and R 6 are hydrogen, alkyl of one to 4 carbon atoms, inclusive, or fluoro, being the same or different, with the proviso that one of R 5 and R 6 is fluoro only when the other is hydrogen or fluoro, wherein X is (1) trans-CH═CH-- (2) cis-CH═CH-- (3) --C.tbd.C-- or (4) --CH 2 CH 2 --, and wherein wavy line (˜) indicates attachment in alpha or beta configuration.