Rumen-stable pellets

Claim 2

A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.5, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen but releases it in the abomasum, said coating comprising (a) a film-forming polymeric material comprising a polymer, copolymer or mixture thereof having a molecular weight of about 5000-300,000, said polymeric material having basic amino groups the nitrogen content of which constitutes between about 2 and about 14% by weight of the polymeric material, (b) a hydrophobic material dispersed in said polymeric material selected from waxes, resins, polymers, fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said hydrophobic material being present in an amount between about 5 and about 50% of the weight of the polymeric material, and said coating making up about 5 to about 50% of the weight of said pellet and having a sticking temperature of at least about 50° C.

Claim 3

A pellet according to claim 1 wherein said polymeric material comprises cellulose propionate morpholinobutyrate or at least one polymer derived from monomers selected from the group consisting of acrylonitrile, vinyl pyridine, styrene, methacrylate and methyl methacrylate.

Claim 4

A pellet according to claim 1 wherein said hydrophobic material is selected from the group consisting of fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group.

Claim 5

Method for producing a pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.5, and a coating which protects the core material in the rumen and releases it in the abomasum surrounding said core material which comprises the steps of forming a coating composition comprising (a) a film-forming polymeric material comprising a polymer, copolymer or mixture thereof having a molecular weight of about 5000-300,000, said polymeric material having basic amino groups the nitrogen content of which constitutes between about 2 and about 14% by weight, of the polymeric material, (b) a hydrophobic material dispersed in said polymeric material selected from the group consisting of waxes, resins, polymers, fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, the weight of said hydrophobic substance being from about 5 to about 50% of the weight of polymeric material, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, and applying said coating to a core material which is beneficial to the ruminant when supplied postruminally in an amount such that said coating makes up about 5 to about 50% of the weight of said pellet, said coating having a sticking temperature of at least about 50° C.

Claim 6

Method for producing a pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.5, and a coating which protects the core material in the rumen and releases it in the abomasum surrounding said core material which comprises the steps of forming a coating composition comprising (a) a film-forming polymeric material comprising a polymer, copolymer or mixture thereof having a molecular weight of about 5000-300,000, said polymeric material having basic amino groups the nitrogen content of which constitutes between about 2 and about 14% by weight, of the polymeric material, (b) a hydrophobic material dispersed in said polymeric material selected from the group consisting of waxes, resins, polymers, fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polyfunctional carboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, the weight of said hydrophobic substance being from about 5 to about 50% of the weight of polymeric material, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, and applying said coating to a core material which is beneficial to the ruminant when supplied postruminally in an amount such that said coating makes up about 5 to about 50% of the weight of said pellet, said coating having a sticking temperature of at least about 50° C.

Claim 7

A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.5, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a film-forming polymeric material containing at least one basic amino grouping in which the nitrogen content is from 2 to 14% by weight of the total molecular weight of the polymeric material, said polymeric material consisting essentially of cellulose propionate morpholinobutyrate, or polymers, copolymers and blends of polymers derived at least in part from monomers selected from the group consisting of 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine, and 2-ethyl-5-vinylpyridine, and (b) a hydrophobic material dispersed in said polymeric material selected from the group consisting of fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said hydrophobic material being present in an amount between about 5 and 50% of the weight of the polymreic material, and said coating making up about 5 to about 50% of the weight of said pellet, and having a sticking temperature of at least about 50° C.

Claim 8

A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.5, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a film-forming polymeric material containing at least one basic amino grouping in which the nitrogen content is from 2 to 14% by weight of the total molecular weight of the polymeric material, said polymeric material consisting essentially of cellulose propionate morpholinobutyrate, or polymers, copolymers and blends of polymers derived at least in part from monomers selected from the group consisting of 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine, and 2-ethyl-5-vinylpyridine, and (b) a hydrophobic material dispersed in said polymeric material selected from the group consisting of fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said hydrophobic material being present in an amount between about 5 and 50% of the weight of the polymreic material, and said coating making up about 5 to about 50% of the weight of said pellet, and having a sticking temperature of at least about 50° C.

Claim 9

A pellet according to claim 5 wherein said core material is selected from the group consisting of L or DL mixtures of isomers of alanine, arginine, methionine, and tyrosine.

Claim 10

A pellet according to claim 5 wherein said polymeric material is cellulose propionate morpholinobutyrate.

Claim 11

A pellet according to claim 5 wherein said polymeric material is a copolymer of 2-methyl-5-vinylpyridine and styrene.

Claim 12

A pellet according to claim 7 wherein said polymeric material is a copolymer consisting essentially of about 80% 2-methyl-5-vinylpyridine and about 20% styrene.

Claim 13

A pellet according to claim 5 wherein said hydrophobic material is aluminum oleate.

Claim 14

A pellet according to claim 5 wherein said hydrophobic material is stearic acid.

Claim 15

A pellet according to claim 5 wherein said hydrophobic material is dimer acid.

Claim 16

A composition adapted for coating pellets orally administrable to a ruminant which protects the core material in the rumen and releases it in the abomasum comprising (a) a film-forming polymeric material containing at least one basic amino group in which the nitrogen content is from 2 to 14% by weight of the total molecular weight of the polymeric material, said polymeric material consisting essentially of cellulose propionate morpholinobutyrate, or polymers, copolymers and blends of polymers derived at least in part from monomers selected from the group consisting of 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine, and 2-ethyl-5-vinylpyridine, and (b) a hydrophobic material dispersed in said polymeric material selected from the group consisting of fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said hydrophobic material being present in an amount between about 5 and about 50% of the weight of the polymeric material and said coating having a sticking temperature of at least about 50° C.

Claim 17

A composition adapted for coating pellets orally administrable to a ruminant which protects the core material in the rumen and releases it in the abomasum comprising (a) a film-forming polymeric material containing at least one basic amino group in which the nitrogen content is from 2 to 14% by weight of the total molecular weight of the polymeric material, said polymeric material consisting essentially of cellulose propionate morpholinobutyrate, or polymers, copolymers and blends of polymers derived at least in part from monomers selected from the group consisting of 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine, and 2-ethyl-5-vinylpyridine, and (b) a hydrophobic material dispersed in said polymeric material selected from the group consisting of fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, and polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, said polymeric material in combination with said hydrophobic substance being physiologically acceptable and resistant to a pH of greater than about 5 but capable of releasing the core of the pellets at a pH of less than about 3.5, said hydrophobic material being present in an amount between about 5 and about 50% of the weight of the polymeric material and said coating having a sticking temperature of at least about 50° C.

Claim 18

A composition according to claim 13 wherein said polymeric material is cellulose propionate morpholinobutyrate.

Claim 19

A composition according to claim 13 wherein said polymeric material is a copolymer of 2-methyl-5-vinylpyridine and styrene.

Claim 20

A composition according to claim 13 wherein said hydrophobic material is aluminum oleate.

Claim 21

A composition according to claim 13 wherein said hydrophobic material is stearic acid.

Claim 22

A composition according to claim 13 wherein said hydrophobic material is dimer acid.