US4181709A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Rumen-stable pellets
Assignee: Adisseo France SAS
•
Filing: 1977-09-02
•
Granted: 1980-01-01
•
Expires: 1997-09-02
Abstract
Abstract Pellets adapted to be orally administered to ruminants are disclosed. The pellets have a core comprising a nutrient and/or medicament, and a coating which protects the core in the environment of the rumen is also provided to allow utilization of the core in the abomasum and/or intestine. The coating comprises a polymeric matrix which is resistant to the mildly acidic environment of the rumen, a hydrophobic substance, a flake material, and reactive acid dispersed throughout the continuous matrix. The core may contain a neutralizer if desired. The continuity of the polymeric matrix is destroyed in the more acidic environment of the abomasum.
Inventors
- 👤 Clarence C. Dannelly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 01:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5015; A23; A23K; A23K20/00; A23K20/10; A23K20/105; A23K20/116; A23K20/132; A23K20/195; A23K20/20; A23K40/00; A23K40/25; A23K40/30; A23K40/35; A61K9/501; A61K9/5021; A61K9/5026; A61K9/5036; A61K9/5042; B; B01; B01J; B01J2/00; B01J2/006; B01J2/16
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
259 words
A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.68, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a film-forming polymeric material containing at least one basic amino group in which the nitrogen content is from 3 to 14% by weight of the total molecular weight of the polymeric material, said polymeric material comprising cellulose propionate morpholinobutyrate, or at least one polymer, copolymer or blend of polymers derived from monomers selected from 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine, and 2-ethyl-5-vinylpyridine, (b) from about 2 to about 40% based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, or polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, (c) from about 10 to about 200%, based on the weight of said polymeric material, of a physiologically acceptable flake material dispersed in said polymeric material, and (d) from about 5 to about 40% by weight based on the weight of said polymer, of a reactive fatty acid, said coating making up about 5 to about 50% of the weight of said pellet, and having a sticking temperature of at least about 50° C.
Claim 2
Dependent Claim
259 words
A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.68, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a film-forming polymeric material containing at least one basic amino group in which the nitrogen content is from 3 to 14% by weight of the total molecular weight of the polymeric material, said polymeric material comprising cellulose propionate morpholinobutyrate, or at least one polymer, copolymer or blend of polymers derived from monomers selected from 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine, and 2-ethyl-5-vinylpyridine, (b) from about 2 to about 40% based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, or polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, (c) from about 10 to about 200%, based on the weight of said polymeric material, of a physiologically acceptable flake material dispersed in said polymeric material, and (d) from about 5 to about 40% by weight based on the weight of said polymer, of a reactive fatty acid, said coating making up about 5 to about 50% of the weight of said pellet, and having a sticking temperature of at least about 50° C.
Claim 3
Dependent Claim
26 words
A pellet according to claim 1 wherein said reactive acid is selected from the group consisting of dimer acid, oleic acid, stearic acid, and palmitic acid.
Claim 4
Dependent Claim
24 words
A pellet according to claim 1 wherein said core material is selected from the group consisting of glucose, bacitracin, thyrotropin releasing factor and inositol.
Claim 5
Dependent Claim
17 words
A pellet according to claim 1 wherein said polymeric material is a copolymer of 2-methyl-5-vinylpyridine and styrene.
Claim 6
Dependent Claim
23 words
A pellet according to claim 3 wherein said polymeric material is a copolymer consisting essentially of about 80% 2-methyl-5-vinylpyridine and about 20% styrene.
Claim 7
Dependent Claim
13 words
A pellet according to claim 1 wherein said hydrophobic material is aluminum oleate.
Claim 8
Dependent Claim
13 words
A pellet according to claim 1 wherein said hydrophobic material is stearic acid.
Claim 9
Dependent Claim
13 words
A pellet according to claim 1 wherein said hydrophobic material is dimer acid.
Claim 10
Dependent Claim
25 words
A pellet according to claim 1 wherein said flake material is selected from the group consisting of metal flake, mineral flake, and crosslinked organic polymer.
Claim 11
Dependent Claim
24 words
A pellet according to claim 9 wherein said flake material is selected from the group consisting of aluminum flake, talc, graphite, and ground mica.
Claim 12
Dependent Claim
224 words
A composition adapted for use in coating pellets orally administrable to a ruminant which protects the core material in the rumen and releases it in the abomasum comprising (a) a film-forming polymeric material containing at least one basic amino group in which the nitrogen content is from 3 to 14% by weight of the total molecular weight of the polymeric material, said polymeric material comprising cellulose propionate morpholinobutyrate, or a polymer, copolymer or blend of polymers derived at least in part from monomers selected from 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine, and 2-ethyl-5-vinylpyridine, and (b) from about 2 to about 40%, based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, or polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, and (c) from about 10 to about 200%, based on the weight of said polymeric material, of a physiologically acceptable flake material dispersed in said polymeric material, and (d) from about 5 to about 40% by weight, based on the weight of said polymer, of a reactive fatty acid, said coating having a sticking temperature of at least about 50° C.
Claim 13
Dependent Claim
224 words
A composition adapted for use in coating pellets orally administrable to a ruminant which protects the core material in the rumen and releases it in the abomasum comprising (a) a film-forming polymeric material containing at least one basic amino group in which the nitrogen content is from 3 to 14% by weight of the total molecular weight of the polymeric material, said polymeric material comprising cellulose propionate morpholinobutyrate, or a polymer, copolymer or blend of polymers derived at least in part from monomers selected from 2-vinylpyridine, 4-vinylpyridine, 2-methyl-5-vinylpyridine, and 2-ethyl-5-vinylpyridine, and (b) from about 2 to about 40%, based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from fatty acids having from 12 to 32 carbon atoms, aluminum salts of fatty acids having from 12 to 32 carbon atoms, or polycarboxylic acids having a ratio of from 10 to 22 carbon atoms per carboxyl group and a molecular weight of from 400 to 1000, and (c) from about 10 to about 200%, based on the weight of said polymeric material, of a physiologically acceptable flake material dispersed in said polymeric material, and (d) from about 5 to about 40% by weight, based on the weight of said polymer, of a reactive fatty acid, said coating having a sticking temperature of at least about 50° C.
Claim 14
Dependent Claim
17 words
A composition according to claim 11 wherein said polymeric material is a copolymer of 2-methyl-5-vinylpyridine and styrene.
Claim 15
Dependent Claim
23 words
A composition according to claim 11 wherein said polymeric material is a copolymer consisting essentially of about 80% 2-methyl-5-vinylpyridine and about 20% styrene.
Claim 16
Dependent Claim
13 words
A composition according to claim 11 wherein said hydrophobic material is aluminum oleate.
Claim 17
Dependent Claim
13 words
A composition according to claim 11 wherein said hydrophobic material is stearic acid.
Claim 18
Dependent Claim
13 words
A composition according to claim 11 wherein said hydrophobic material is dimer acid.
Claim 19
Dependent Claim
25 words
A composition according to claim 11 wherein said flake material is selected from the group consisting of metal flake, mineral flake, and crosslinked organic polymer.
Claim 20
Dependent Claim
24 words
A composition according to claim 17 wherein said flake material is selected from the group consisting of aluminum flake, talc, graphite, and ground mica.
Claim 21
Dependent Claim
188 words
A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.68, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a film-forming copolymer of about 80% 2-methyl-5-vinylpyridine and about 20% styrene by weight, (b) from about 2 to about 40% based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from aluminum oleate, dimer acid, stearic acid or oleic acid, (c) from about 10 to about 200%, based on the weight of said polymeric material, of at least one physiologically acceptable flake material dispersed in said polymeric material selected from the group consisting of talc, aluminum flake and graphite, and (d) from about 5 to about 40% by weight, based on the weight of said polymer, of a reactive fatty acid, said coating making up about 5 to about 50% by weight of said pellet, and having a sticking temperature of at least about 50° C.
Claim 22
Dependent Claim
188 words
A pellet adapted for oral administration to a ruminant comprising a core material having a pH greater than about 5.68, said core material being beneficial to the ruminant postruminally, and a coating surrounding said core material which protects the core material in the rumen and releases it in the abomasum, said coating comprising (a) a film-forming copolymer of about 80% 2-methyl-5-vinylpyridine and about 20% styrene by weight, (b) from about 2 to about 40% based on the weight of said polymeric material, of a hydrophobic material dispersed in said polymeric material selected from aluminum oleate, dimer acid, stearic acid or oleic acid, (c) from about 10 to about 200%, based on the weight of said polymeric material, of at least one physiologically acceptable flake material dispersed in said polymeric material selected from the group consisting of talc, aluminum flake and graphite, and (d) from about 5 to about 40% by weight, based on the weight of said polymer, of a reactive fatty acid, said coating making up about 5 to about 50% by weight of said pellet, and having a sticking temperature of at least about 50° C.
References Cited (Backward Citations)
US4060598A
Cited
US3577512A
Cited
US3829564A
Cited
US3832252A
Cited
US3880990A
Cited
US3917813A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-31 | 1983-07-02 | 1984-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-31 | 1987-07-02 | 1988-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-31 | 1991-07-02 | 1992-01-01 | $7700.00 | Window Closed / Lapsed |