Patent US4180670A successfully refreshed from Google Patents.
US4180670A
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Amino pyridine derivatives
Assignee: John Wyeth and Brother Ltd
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Filing: 1978-01-30
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Granted: 1979-12-25
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Expires: 1998-01-30
Abstract
Abstract Novel 4-pyridinamine derivatives having the formula ##STR1## [where R 1 and R 2 are aryl or heteroaryl (optionally linked together by a lower alkylene bridge) or one of R 1 and R 2 is aryl or heteroaryl and the other of R 1 and R 2 is lower alkyl or ar(lower)alkyl, R 3 and R 4 are each hydrogen or lower alkyl and n is 0 or 1] and their non-toxic acid addition salts are described. They show CNS activity and may be used as antidepressant drugs. Some also show stimulant activity. Novel intermediates having the formula ##STR2## are also described.
Inventors
- 👤 Edwin T. Edington
- 👤 Alan C. White
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 09:32
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/74; C07D213/75
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
106 words
A compound selected from those having the formula ##STR18## and their pharmaceutically acceptable acid addition salts, wherein one of R 1 and R 2 is selected from phenyl; naphthyl; phenyl substituted by one or two substituents selected from halogen, lower alkyl, lower alkoxy, lower alkylenedioxy and trifluoromethyl; thienyl; and pyridyl and the other one of R 1 and R 2 is selected from phenyl; naphthyl; phenyl substituted by one or two substituents selected from halogen, lower alkyl, lower alkoxy, lower alkylenedioxy, trifluoromethyl; thienyl; and pyridyl R 3 and R 4 are independently selected from hydrogen and lower alkyl and n is selected from 0 and 1.
Claim 2
Dependent Claim
106 words
A compound selected from those having the formula ##STR18## and their pharmaceutically acceptable acid addition salts, wherein one of R 1 and R 2 is selected from phenyl; naphthyl; phenyl substituted by one or two substituents selected from halogen, lower alkyl, lower alkoxy, lower alkylenedioxy and trifluoromethyl; thienyl; and pyridyl and the other one of R 1 and R 2 is selected from phenyl; naphthyl; phenyl substituted by one or two substituents selected from halogen, lower alkyl, lower alkoxy, lower alkylenedioxy, trifluoromethyl; thienyl; and pyridyl R 3 and R 4 are independently selected from hydrogen and lower alkyl and n is selected from 0 and 1.
Claim 3
Dependent Claim
19 words
A compound as defined in claim 1, which is selected from N-(diphenylmethyl)-4-pyridinamine and its pharmaceutically acceptable acid addition salts.
Claim 4
Dependent Claim
19 words
A compound as defined in claim 1, which is selected from N-[(di-p-fluorophenyl)methyl]-4-pyridinamine and its pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
19 words
A compound as defined in claim 1, which is selected from N-[α-(2-methylphenyl)benzyl]-4-pyridinamine and its pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
19 words
A compound as defined in claim 1, which is selected from N-[α-(2-thienyl)benzyl]-4-pyridinamine and its pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
19 words
A compound as defined in claim 1, which is selected from N-[α-(2-methoxyphenyl)benzyl]-4-pyridinamine and its pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
19 words
A compound as defined in claim 1, which is selected from N-[α-(2-pyridyl)benzyl]-4-pyridinamine and its pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
19 words
A compound as defined in claim 1, which is selected from N-(2,2-diphenylethyl)-4-pyridinamine and its pharmaceutically acceptable acid addition salts.
Claim 10
Dependent Claim
19 words
A compound as defined in claim 1 which is selected from N-(diphenylmethyl)-N-methyl-4-pyridinamine and its pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
US2974139A
Cited
US3926611A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-24 | 1983-06-25 | 1983-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-24 | 1987-06-25 | 1987-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-24 | 1991-06-25 | 1991-12-25 | $7700.00 | Window Closed / Lapsed |