Patent US3756220A successfully refreshed from Google Patents.
Patent US4180558A successfully refreshed from Google Patents.
US4180558A
Expired / Lapsed
US
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Unit dosage forms
Assignee: Hoffmann La Roche Inc
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Filing: 1978-08-21
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Granted: 1979-12-25
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Expires: 1998-08-21
Abstract
Abstract Use of an improved water-swellable carboxymethylcellulose paper in a unique pharmaceutical unit dosage form comprising a stack of edible webs laminated at the edges at least some of which are paper is described. The subject paper is a superior delaminating agent in said unit dosage forms.
Inventors
- 👤 Arthur H. Goldberg
- 👤 Michael L. Franklin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 06:21
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31971; Y10T428/31975; Y10T428/31978
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
148 words
In a solid pharmaceutical unit dosage form comprising a laminate composed of a plurality of layers of an edible, therapeutically inert web, at least one of said layers having one or more medicaments loaded on to one or more surfaces, said layers of web arranged in said laminate so that substantially no medicament is loaded to an outer surface thereof, said laminate being sealed only at the edges so as to completely internalize said medicament, the improvement which comprises controlling the dissolution rate of said laminate by including therein at least one web of an improved paper composition formed from an aqueous alcholic fibrous slurry and consisting essentially of water-soluble carboxymethylcellulose fibers and water-insoluble, water-swellable, cross-linked carboxymethylcellulose fibers, said web by not greater than 20% soluble in water, the rate of disolution of said laminate being directly related to the density of said web of improved paper composition.
Claim 2
Dependent Claim
148 words
In a solid pharmaceutical unit dosage form comprising a laminate composed of a plurality of layers of an edible, therapeutically inert web, at least one of said layers having one or more medicaments loaded on to one or more surfaces, said layers of web arranged in said laminate so that substantially no medicament is loaded to an outer surface thereof, said laminate being sealed only at the edges so as to completely internalize said medicament, the improvement which comprises controlling the dissolution rate of said laminate by including therein at least one web of an improved paper composition formed from an aqueous alcholic fibrous slurry and consisting essentially of water-soluble carboxymethylcellulose fibers and water-insoluble, water-swellable, cross-linked carboxymethylcellulose fibers, said web by not greater than 20% soluble in water, the rate of disolution of said laminate being directly related to the density of said web of improved paper composition.
Claim 3
Dependent Claim
33 words
The improved laminate in accordance with claim 1 wherein for each 1 to 3 layers of web having medicament loaded thereto in said laminate there is present one layer of said improved web.
Claim 4
Dependent Claim
30 words
The improved laminate in accordance with claim 1 wherein there is present two layers of said improved web for each layer of web having medicament loaded thereto in said laminate.
References Cited (Backward Citations)
US4029758A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-24 | 1983-06-25 | 1983-12-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-24 | 1987-06-25 | 1987-12-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-24 | 1991-06-25 | 1991-12-25 | $7700.00 | Window Closed / Lapsed |