Sulfam(na)phthaleins

Claim 2

A compound of the formula ##STR36## wherein A is a 4'-hydroxy-1'-phenyl moiety or a 4'-hydroxy-1'-naphthyl moiety; B is a phenyl moiety or a naphthyl moiety, provided A is said 4'-hydroxy-1'-phenyl moiety when B is said naphthyl moiety; X represents the carbon atoms necessary to complete 2,3-dihydrobenz[d]isothiazole-1,1-dioxide or 2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxide; and Y is an electron-withdrawing group having a positive sigma value greater than 0.60 as defined by Hammett's Equation.

Claim 3

A compound as defined in claim 1 wherein Y is --CN.

Claim 4

A compound as defined in claim 1 wherein Y is --SO 2 CH 3 .

Claim 5

A compound as defined in claim 1 wherein Y is ##STR37##

Claim 6

A compound as defined in claim 1 wherein Y is ##STR38##

Claim 7

A compound of the formula ##STR39## wherein R 1 and R 2 each are selected from hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms; chloro and fluoro; R 3 is hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms or hydroxy; R 2 and R 3 taken together represent the carbon atoms necessary to complete a fused benzene ring; R 4 and R 6 each are selected from hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, chloro and fluoro; R 7 is hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; R 6 and R 7 taken together represent the carbon atoms necessary to complete a fused benzene ring provided R 2 and R 3 are taken separately when R 6 and R 7 are taken together; R 5 is selected from hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, --N,N--(dialkyl)amino wherein each alkyl contains 1 to 4 carbon atoms, --N,N--(w-R 8 alkyl) 2 amino wherein R 8 is hydroxy or halo and said alkyl contains 1 to 4 carbon atoms, --NHCOCH 3 , piperidino, pyrrolidino, N-methylpiperazino, morpholino, thiomorpholino or tetrahydro-2H,4H-1,3,6-dioxazocino; R 4 , R 5 and R 6 taken together represent the atoms necessary to complete a fused [ij]quinolizidine ring; X represents the atoms necessary to complete 2,3-dihydrobenz[d]isothiazole-1,1-dioxide or 2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxide; and Y is an electron-withdrawing group having a positive sigma value greater than 0.60 as defined by Hammett's Equation.

Claim 8

A compound of the formula ##STR39## wherein R 1 and R 2 each are selected from hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms; chloro and fluoro; R 3 is hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms or hydroxy; R 2 and R 3 taken together represent the carbon atoms necessary to complete a fused benzene ring; R 4 and R 6 each are selected from hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, chloro and fluoro; R 7 is hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; R 6 and R 7 taken together represent the carbon atoms necessary to complete a fused benzene ring provided R 2 and R 3 are taken separately when R 6 and R 7 are taken together; R 5 is selected from hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, --N,N--(dialkyl)amino wherein each alkyl contains 1 to 4 carbon atoms, --N,N--(w-R 8 alkyl) 2 amino wherein R 8 is hydroxy or halo and said alkyl contains 1 to 4 carbon atoms, --NHCOCH 3 , piperidino, pyrrolidino, N-methylpiperazino, morpholino, thiomorpholino or tetrahydro-2H,4H-1,3,6-dioxazocino; R 4 , R 5 and R 6 taken together represent the atoms necessary to complete a fused [ij]quinolizidine ring; X represents the atoms necessary to complete 2,3-dihydrobenz[d]isothiazole-1,1-dioxide or 2,3-dihydronaphtho[1,8-de]-1,2-thiazine-1,1-dioxide; and Y is an electron-withdrawing group having a positive sigma value greater than 0.60 as defined by Hammett's Equation.

Claim 9

A compound as defined in claim 6 wherein Y is --CN.

Claim 10

A compound as defined in claim 6 wherein Y is --SO 2 CH 3 .

Claim 11

A compound as defined in claim 6 wherein Y is ##STR40##

Claim 12

A compound as defined in claim 6 wherein Y is ##STR41##

Claim 13

A compound as defined in claim 6 wherein said R 1 and R 2 each are alkyl.

Claim 14

A compound as defined in claim 11 wherein said R 3 is hydrogen.

Claim 15

A compound as defined in claim 6 wherein said R 1 and R 2 each are alkoxy.

Claim 16

A compound as defined in claim 13 wherein said R 3 is hydrogen.

Claim 17

A compound as defined in claim 12 wherein said R 5 is hydroxy.

Claim 18

A compound as defined in claim 15 wherein said R 4 and R 6 are alkyl and said R 7 is hydrogen.

Claim 19

A compound as defined in claim 14 wherein said R 5 is hydroxy.

Claim 20

A compound as defined in claim 17 wherein said R 4 and R 6 are alkoxy and said R 7 is hydrogen.

Claim 21

A compound as defined in claim 16 wherein said R 1 , R 2 , R 4 and R 6 each are methyl.

Claim 22

A compound as defined in claim 18 wherein said R 1 , R 2 , R 4 and R 6 each are methoxy.

Claim 23

A compound as defined in claim 12 wherein said R 1 and R 2 are methyl and R 4 , R 6 and R 7 are hydrogen.

Claim 24

A compound as defined in claim 21 wherein said R 5 is morpholino.

Claim 25

A compound as defined in claim 21 wherein said R 5 is --N,N--(dialkyl)amino.

Claim 26

A compound as defined in claim 21 wherein said R 5 is --N,N--(w--R 8 alkyl) 2 amino.

Claim 27

A compound as defined in claim 21 wherein said R 5 is alkoxy.

Claim 28

A compound as defined in claim 21 wherein said R 5 is --NHCOCH 3 .

Claim 29

A compound as defined in claim 21 wherein said R 5 is pyrrolidino.

Claim 30

A compound as defined in claim 21 wherein said R 5 is tetrahydro-2H,4H-1,3,6-dioxazocino.

Claim 31

A compound as defined in claim 12 wherein said R 1 and R 2 are methyl, R 4 is hydrogen, R 5 is --N,N--(dialkyl)-amino and R 6 and R 7 represent the carbon atoms necessary to complete a fused benzene ring.

Claim 32

A compound as defined in claim 12 wherein said R 1 and R 2 are methyl, R 4 and R 6 are hydrogen, R 5 is --N,N--(dialkyl)amino and R 7 is alkyl.

Claim 33

A compound as defined in claim 12 wherein said R 1 and R 2 are methyl, R 4 , R 5 and R 6 are hydrogen and R 7 is hydroxy.

Claim 34

A compound as defined in claim 14 wherein said R 1 and R 2 are methoxy, R 4 and R 6 are hydrogen and R 5 and R 7 are alkoxy.

Claim 35

A compound as defined in claim 6 wherein said R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are hydrogen.

Claim 36

The compound ##STR42##

Claim 37

The compound ##STR42##

Claim 38

The compound ##STR43##

Claim 39

The compound ##STR43##

Claim 40

The compound ##STR44##

Claim 41

The compound ##STR44##

Claim 42

The compound ##STR45##

Claim 43

The compound ##STR45##

Claim 44

The compound ##STR46##

Claim 45

The compound ##STR46##

Claim 46

The compound ##STR47##

Claim 47

The compound ##STR47##

Claim 48

The compound ##STR48##

Claim 49

The compound ##STR48##