US4177290A
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Acetamide derivatives
Assignee: Cephalon France SAS
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Filing: 1978-03-09
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Granted: 1979-12-04
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Expires: 1998-03-09
Abstract
Abstract Novel acetamide derivatives have been discovered to have useful pharmaceutical activity on the central nervous system. They may be prepared by reacting the corresponding ester or acid halide with the appropriately substituted amine.
Inventors
- 👤 Louis Lafon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 22:18
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/12; C07D295/125; C07D295/13; A; A61; A61P; A61P25/00; A61P25/26; C07C; C07C317/00; C07C321/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
161 words
An acetamide derivative selected from the compounds of formula I ##STR8## wherein ring a and ring b are each substituted zero, one or more times by substituents selected from the group consisting of fluoro, chloro, bromo, trifluoromethyl, nitro, amino, alkyl of 1 to 4 carbon atoms, inclusive, alkoxy of 1 to 4 carbon atoms, inclusive, and methylenedioxy; wherein Z is the radical >CHSO--; and wherein A is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, inclusive, hydroxyalkyl of 1 to 4 carbon atoms, inclusive, and a group of formula R 1 R 2 N--Y--wherein Y is a divalent linear or branched chain hydrocarbon radical having 1 to 4 carbon atoms, inclusive, in the chain, and R 1 and R 2 , being the same or different, are selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, inclusive; and addition salts of the compounds wherein A is a basic group.
Claim 2
Dependent Claim
161 words
An acetamide derivative selected from the compounds of formula I ##STR8## wherein ring a and ring b are each substituted zero, one or more times by substituents selected from the group consisting of fluoro, chloro, bromo, trifluoromethyl, nitro, amino, alkyl of 1 to 4 carbon atoms, inclusive, alkoxy of 1 to 4 carbon atoms, inclusive, and methylenedioxy; wherein Z is the radical >CHSO--; and wherein A is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, inclusive, hydroxyalkyl of 1 to 4 carbon atoms, inclusive, and a group of formula R 1 R 2 N--Y--wherein Y is a divalent linear or branched chain hydrocarbon radical having 1 to 4 carbon atoms, inclusive, in the chain, and R 1 and R 2 , being the same or different, are selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, inclusive; and addition salts of the compounds wherein A is a basic group.
Claim 3
Dependent Claim
62 words
A compound of claim 1 wherein A is R 1 R 2 N--Y--wherein Y is a divalent linear or branched chain hydrocarbon radical having 1 to 4 carbon atoms, inclusive, in the chain, and R 1 and R 2 , together with the N atom to which they are attached, form a group selected from the group consisting of dimethylamine and diethylamine.
Claim 4
Dependent Claim
24 words
A compound of claim 1 wherein rings a and b are both unsubstituted and A is hydrogen, and pharmacologically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
8 words
A compound of claim 1 which is benzhydrylsulphinylacetamide.
Claim 6
Dependent Claim
27 words
A pharamaceutical composition having activity on the central nervous system and consisting of, as an essential active ingredient, an active amount of a compound of claim 1.
Claim 7
Dependent Claim
28 words
The compound of claim 1, wherein Z is --CHSO-- and A is hydrogen, alkyl of 1 to 4 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms.
References Cited (Backward Citations)
US3993683A
Cited
US4062973A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-03 | 1983-06-04 | 1983-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-03 | 1987-06-04 | 1987-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-03 | 1991-06-04 | 1991-12-04 | $7700.00 | Window Closed / Lapsed |