US4062973A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sulfur-containing derivatives of cyclohexylphenyl-ethane
Assignee: Boehringer Ingelheim GmbH
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Filing: 1976-10-06
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Granted: 1977-12-13
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Expires: 1996-10-06
Abstract
Abstract Compounds of the formula <IMAGE> wherein R1 is hydrogen or halogen, R2 is hydroxyl, alkoxy of 1 to 6 carbon atoms, aralkoxy of 7 to 10 carbon atoms, amino, (alkyl of 1 to 3 carbon atoms)-amino, piperidino or morpholino, and N IS 0, 1 OR 2, DIASTEREOISOMERS THEREOF AND, WHEN R2 is hydroxyl, non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds, their diastereoisomers and the salts are useful as antithrombotics, anti-hypercholesteremics and anti-hyperglyceridemics.
Inventors
- 👤 Josef Nickl
- 👤 Berthold Narr
- 👤 Erich Muller
- 👤 Josef Roch
- 👤 Walter Haarmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 10:45
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/18; C07D295/182; C07D295/185; A; A61; A61P; A61P7/00; A61P7/02; C07C; C07C317/00; C07C317/44; C07C323/00; C07C323/50; C07C323/51; C07C323/52; C07C323/60
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
61 words
A compound of the formula ##STR7## wherein R 1 is hydrogen or halogen, R 2 is hydroxyl, alkoxy of 1 to 6 carbon atoms or aralkoxy of 7 to 10 carbon atoms, and n is 0, 1 or 2, a diastereoisomer thereof or, when R 2 is hydroxyl, a non-toxic, pharmacologically acceptable salt thereof formed with an inorganic or organic base.
Claim 2
Dependent Claim
61 words
A compound of the formula ##STR7## wherein R 1 is hydrogen or halogen, R 2 is hydroxyl, alkoxy of 1 to 6 carbon atoms or aralkoxy of 7 to 10 carbon atoms, and n is 0, 1 or 2, a diastereoisomer thereof or, when R 2 is hydroxyl, a non-toxic, pharmacologically acceptable salt thereof formed with an inorganic or organic base.
Claim 3
Dependent Claim
33 words
A compound of claim 1, wherein R 1 is hydrogen or chlorine, R 2 is hydroxyl, methoxy, ethoxy, propoxy , isopropoxy, butoxy, isoamyloxy, hexyloxy or benzyloxy, and n is 0, 1 or 2.
Claim 4
Dependent Claim
20 words
A compound of claim 1, which is [1-(4'-cyclohexyl-phenyl)-ethylsulfinyl]-acetic acid having a melting point of 152°-154° C, or a salt thereof.
Claim 5
Dependent Claim
16 words
The compound of claim 1, which is ethyl [1-(4'-cyclohexyl-phenyl)-ethylsulfinyl]-acetate having a melting point of 113°-115° C.
Claim 6
Dependent Claim
16 words
The compound of claim 1, which is methyl [1-(3'-chloro-4'-cyclohexyl-phenyl)-ethylsulfinyl]-acetate having a melting point of 93°-95° C.
Claim 7
Dependent Claim
16 words
The compound of claim 1, which is ethyl [1-(3'-chloro-4'-cyclohexyl-phenyl)-ethylsulfinyl]-acetate having a melting point of 80°-82° C.
Claim 8
Dependent Claim
24 words
An antithrombotic pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective antithrombotic amount of a compound of claim 1.
Claim 9
Dependent Claim
31 words
The method of preventing or relieving thrombosis in a warm-blooded animal, which comprises perorally, parenterally or rectally administering to said animal an effective antithrombotic amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-12 | 1981-06-13 | 1981-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-12 | 1985-06-13 | 1985-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-12 | 1989-06-13 | 1989-12-13 | $7700.00 | Window Closed / Lapsed |