US4000183A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Adamantyl-phenoxy- and phenylthio-alkyl-alkanoyl esters
Assignee: Novartis Corp
•
Filing: 1975-08-18
•
Granted: 1976-12-28
•
Expires: 1995-08-18
Abstract
Abstract Compounds of the formula I r.sub.1 -- ph -- X -- alk -- R.sub.2 (I) wherein R 1 is adamantyl, Ph is phenylene which is optionally substituted by amino, nitro, lower alkyl, lower alkoxy, halogen or trifluoromethyl, X is oxy or thio, alk is alkylene with 1 to 20 C atoms or alkenylene with 2 to 20 C atoms and R 2 is free, esterified or amidised carboxyl, sulpho or sulphonamido and therapeutically acceptable salts thereof are useful as anti-allergic and hypolipidaemic agents.
Inventors
- 👤 Georges Haas
- 👤 Roland Jaques
- 👤 Alberto Rossi
- 👤 Martin Ruegg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 14:02
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07C309/00; C07C309/01; C07C309/02; C07C309/03; C07C309/07; C07C309/09; C07C59/70
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
131 words
A compound of the formula R.sub.1 -- Ph -- X -- alk -- R.sub.2 wherein R 1 is unsubstituted adamantyl, Ph is unsubstituted phenylene, or phenylene substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, X is oxy, thio, sulphinyl or sulphonyl, alk is unbranched alkylene with up to 10 carbon atoms which may carry an unbranched alkyl radical with up to 8 carbon atoms in the α-position with respect to R 2 , or is unbranched alkenylene with up to 7 carbon atoms the double bond of which extend from the carbon atom in α- or β-position to R 2 and which may carry an unbranched alkyl radical with up to 3 carbon atoms in α- or β-position with respect to R 2 , and R 2 denotes lower alkanoyloxy.
Claim 2
Dependent Claim
131 words
A compound of the formula R.sub.1 -- Ph -- X -- alk -- R.sub.2 wherein R 1 is unsubstituted adamantyl, Ph is unsubstituted phenylene, or phenylene substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, X is oxy, thio, sulphinyl or sulphonyl, alk is unbranched alkylene with up to 10 carbon atoms which may carry an unbranched alkyl radical with up to 8 carbon atoms in the α-position with respect to R 2 , or is unbranched alkenylene with up to 7 carbon atoms the double bond of which extend from the carbon atom in α- or β-position to R 2 and which may carry an unbranched alkyl radical with up to 3 carbon atoms in α- or β-position with respect to R 2 , and R 2 denotes lower alkanoyloxy.
Claim 3
Dependent Claim
57 words
A compound as claimed in claim 1 wherein R 1 is unsubstituted adamantyl, Ph is 1,4-phenylene, X is oxy or thio, alk is --(CH 2 ) n --CH(R 3 )-- wherein n is 0, 1 or 2 and R 3 is hydrogen or straight-chain alkyl with 1 to 8 carbon atoms, and R 2 is lower alkanoyloxy.
References Cited (Backward Citations)
US3880916A
Cited
US3928363A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-28 | 1980-06-28 | 1980-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-28 | 1984-06-28 | 1984-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-28 | 1988-06-28 | 1988-12-28 | $7700.00 | Window Closed / Lapsed |