Patent US4177272A successfully refreshed from Google Patents.
US4177272A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Disubstituted piperazines
Assignee: Science Union et Cie
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Filing: 1977-12-27
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Granted: 1979-12-04
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Expires: 1997-12-27
Abstract
Abstract Disubstituted piperazines of the formula: ##STR1## wherein: ##STR2## is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, Δ 3 -chromenyl, thiochromanyl or Δ 3 -thiochromenyl, X is nitrogen and simultaneously Y is oxygen or sulfur, or X is sulfur, imino (NH) or methylimino (N CH 3 ) and simultaneously Y is nitrogen, and R is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl. These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.
Inventors
- 👤 Gilbert Regnier
- 👤 Roger Canevari
- 👤 Michel Laubie
- 👤 Jean-Claude Poignant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:24
CPC Classifications
C; C07; C07D; C07D271/00; C07D271/02; C07D271/06; C07D271/07; A; A61; A61P; A61P25/00; A61P9/00; A61P9/12; C07D249/00; C07D249/02; C07D249/08; C07D249/10; C07D249/14; C07D285/00; C07D285/01; C07D285/02; C07D285/04; C07D285/08; C07D285/12; C07D285/125; C07D285/135
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
37 words
A compound of the formula ##STR12## wherein the group ##STR13## is selected from the group consisting of naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, Δ 3 -chromenyl, thiochromanyl and Δ 3 -thiochromenyl.
Claim 2
Dependent Claim
37 words
A compound of the formula ##STR12## wherein the group ##STR13## is selected from the group consisting of naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, Δ 3 -chromenyl, thiochromanyl and Δ 3 -thiochromenyl.
Claim 3
Dependent Claim
21 words
A compound of claim 1, wherein ##STR14## is selected from the group consisting of benzo [b] furanyl, benzodioxolyl, benzodioxanyl and coumaranyl.
Claim 4
Dependent Claim
8 words
A compound of claim 1 which is 1-piperonyl-4-(1,3,4-thiadiazol-2-yl)-piperazine.
Claim 5
Dependent Claim
8 words
A compound of claim 1, which is 1-(3,4-ethylenedioxybenzyl)-4-(1,3,4-thiadiazol-2-yl)-piperazine.
Claim 6
Dependent Claim
10 words
A compound of claim 1, which is 1-(5-benzo [b] furanylmethyl)-4-(1,3,4-thiadiazol-2yl)-piperazine.
Claim 7
Dependent Claim
31 words
A pharmaceutical composition for treating peripheral vascular disorders or Parkinson's disease containing as active ingredient an effective amount of a compound of claim 1, together with a suitable pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
37 words
A method for treating a living animal body afflicted with peripheral vascular disorders or Parkinson's disease, comprising the step of administering an effective amount of a compound of claim 1 for the alleviation of the said conditions.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-03 | 1983-06-04 | 1983-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-03 | 1987-06-04 | 1987-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-03 | 1991-06-04 | 1991-12-04 | $7700.00 | Window Closed / Lapsed |