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Patent US4172940A successfully refreshed from Google Patents.
US4172940A
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Purification of C-076 compounds by single column chromatography
Assignee: Merck and Co Inc
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Filing: 1977-10-03
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Granted: 1979-10-30
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Expires: 1997-10-03
Abstract
Abstract This case relates to a novel process for aiding in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a bed of activated alumina and a bed of activated carbon, respectively. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.
Inventors
- 👤 Louis Chaiet
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:35
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/01; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/44; C12P19/60; C12P19/62; C12P19/623; C12R; C12R2001/00; C12R2001/01; C12R2001/465
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
117 words
A method for removing impurities from C-076 non-polar solvent solutions in which said C-076 compounds have the formula: ##STR3## wherein R is the α-L-oleandrosyl-α-L-oleandroside of the structure: ##STR4## and wherein the broken line indicates a single or a double bond; R 1 is hydroxy and is present only when said broken line indicates a single bond R 2 is propyl or butyl; and R 3 is methoxy or hydroxy, wherein said solvent solution is passed through a single column containing both a bed of acid washed activated alumina and a bed of activated carbon, respectfully followed by elution with a non polar solvent selected from methylene chloride, chloroform, benzene or hexane containing from about 1-10% of isopropanol.
Claim 2
Independent Claim
117 words
A method for removing impurities from C-076 non-polar solvent solutions in which said C-076 compounds have the formula: ##STR3## wherein R is the α-L-oleandrosyl-α-L-oleandroside of the structure: ##STR4## and wherein the broken line indicates a single or a double bond; R 1 is hydroxy and is present only when said broken line indicates a single bond R 2 is propyl or butyl; and R 3 is methoxy or hydroxy, wherein said solvent solution is passed through a single column containing both a bed of acid washed activated alumina and a bed of activated carbon, respectfully followed by elution with a non polar solvent selected from methylene chloride, chloroform, benzene or hexane containing from about 1-10% of isopropanol.
References Cited (Backward Citations)
US3950360A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-29 | 1983-04-30 | 1983-10-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-29 | 1987-04-30 | 1987-10-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-29 | 1991-04-30 | 1991-10-30 | $7700.00 | Window Closed / Lapsed |