Patent US4172143A successfully refreshed from Google Patents.
US4172143A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Methoxy-benzamide derivatives
Assignee: Synthelabo SA
•
Filing: 1977-06-16
•
Granted: 1979-10-23
•
Expires: 1997-06-16
Abstract
Abstract The invention provides novel 2-methoxy-benzamide derivatives of the formula: ##STR1## WHEREIN, M IS AN INTEGER FROM 2 TO 5; A is a linear or branched alkylene chain of 1 to 4 carbon atoms; R 2 is chlorine, SO 2 R 5 or SO 2 NR 6 R 7 ; R 3 is hydrogen or alkyl of 1 to 4 carbon atoms; R 5 is alkyl of 1 to 4 carbon atoms; EACH OF R 6 and R 7 is independently hydrogen or alkyl of 1 to 4 carbon atoms in the form of racemates or optical isomers and their pharmaceutically acceptable acid addition salts which are useful in the treatment of psychosomatic and psychotic disturbances.
Inventors
- 👤 Jean-Pierre Kaplan
- 👤 Bernard M. Raizon
- 👤 Daniel C. L. Obitz
- 👤 Philippe M. J. Manoury
- 👤 Henry Najer
- 👤 Maurice Jalfre
- 👤 Don P. R. L. Giudicelli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 06:42
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/18; C07D207/22; C07D207/24; C07D207/26; C07D207/263; C07D207/27; C07D207/04; C07D207/08; C07D207/20; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/18; C07D211/26; C07D211/68; C07D211/70; C07D211/72; C07D211/74; C07D211/76
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
100 words
A 2-methoxy-benzamide of the formula: ##STR86## wherein, m is an integer from 2 to 5; A is a linear or branched alkylene chain of 1 to 4 carbon atoms; R 2 is chlorine, SO 2 R 5 or SO 2 NR 6 R 7 ; R 3 is hydrogen or alkyl of 1 to 4 carbon atoms; R 5 is alkyl of 1 to 4 carbon atoms; each of R 6 and R 7 is independently hydrogen or alkyl of 1 to 4 carbon atoms in the form of racemates or optical isomers and their pharmaceutically acceptible acid addition salts.
Claim 2
Dependent Claim
100 words
A 2-methoxy-benzamide of the formula: ##STR86## wherein, m is an integer from 2 to 5; A is a linear or branched alkylene chain of 1 to 4 carbon atoms; R 2 is chlorine, SO 2 R 5 or SO 2 NR 6 R 7 ; R 3 is hydrogen or alkyl of 1 to 4 carbon atoms; R 5 is alkyl of 1 to 4 carbon atoms; each of R 6 and R 7 is independently hydrogen or alkyl of 1 to 4 carbon atoms in the form of racemates or optical isomers and their pharmaceutically acceptible acid addition salts.
Claim 3
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-sulphamoyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 4
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-sulphamoyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 5
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-methylsulphonyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-methylsulphonyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-ethylsulphonyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-ethylsulphonyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 9
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-dimethylsulphamoyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 10
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-dimethylsulphamoyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 11
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-chloro-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 12
Dependent Claim
12 words
Racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-chloro-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 13
Dependent Claim
29 words
A method of treating psychosomatic or psychotic disturbances in a patient, which method comprises administering to the patient an effective amount of a compound as claimed in claim 1.
Claim 14
Dependent Claim
27 words
A method of treating psychosomatic disturbances in a patient, which method comprises administering to the patient an effective amount of a compound as claimed in claim 2.
Claim 15
Dependent Claim
21 words
The method of claim 7, wherein said compound is racemic N-[(1-cyclopentylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-sulphamoyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 16
Dependent Claim
21 words
The method of claim 7, wherein said compound is racemic N-[(1-cyclohexylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-sulphamoyl-benzamide, its optical isomers and their pharmaceutically, acceptable acids addition salts.
Claim 17
Dependent Claim
20 words
The method of claim 7, wherein said compound is racemic-N-[(1-cyclobutylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-sulphamoyl-benzamide, its optical isomers and their pharmaceutically acceptable acid addition salts.
Claim 18
Dependent Claim
29 words
A pharmaceutical composition capable of treating a psychosomatic or psychotic disturbance which comprises an effective amount of a compound of claim 1 to treat said psychosomatic or psychotic disturbance.
Claim 19
Dependent Claim
22 words
A pharmaceutical composition of claim 12 containing, as active ingredient, racemic N-[(1-cyclopropylmethyl-pyrrolidinyl-2)-methyl]-2-methoxy-5-sulphamoyl-benzamide, its optical isomers or pharmaceutically acceptable acid addition salts thereof.
References Cited (Backward Citations)
DD67123A
Cited
US3342826A
Cited
US3923829A
Cited
US3862139A
Cited
DE2442885A1
Cited
US3975434A
Cited
DE2452405A1
Cited
DE2459221A1
Cited
US4029673A
Cited
US4021567A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-22 | 1983-04-23 | 1983-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-22 | 1987-04-23 | 1987-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-22 | 1991-04-23 | 1991-10-23 | $7700.00 | Window Closed / Lapsed |