Patent US4171544A successfully refreshed from Google Patents.
US4171544A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bonding of bone to materials presenting a high specific area, porous, silica-rich surface
Assignee: University of Florida Research Foundation Inc
•
Filing: 1978-04-05
•
Granted: 1979-10-23
•
Expires: 1998-04-05
Abstract
Abstract Compositions possessing a porous, high specific area, silica-rich surface, or capable of developing such a surface in vivo, form strong bonds with bone tissue. These compositions are thus excellent materials for dental and surgical implants, or the coatings thereof. Examples of such compositions include highly porous glasses and glass-ceramics comprising at least about 80 weight percent silicon dioxide, hardened inorganic cements such as Portland cement and known silicon dioxide-based biologically active glasses and glass-ceramics. Neither calcium, sodium nor phoshorus compounds are necessary ingredients. Cements which develop the above described surface characteristics in vivo form a strong bond with both bone and implant when used in the fixation of dental and surgical implants, especially those made or coated with a biologically active silicon dioxide-based glass or glass-ceramic.
Inventors
- 👤 Larry L. Hench
- 👤 Michael M. Walker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:42
CPC Classifications
C; C03; C03C; C03C4/00; C03C4/0007; A; A61; A61C; A61C8/00; A61C8/0012; A61C8/0013; A61F; A61F2/00; A61F2/02; A61F2/28; A61L; A61L27/00; A61L27/02; A61L27/10; A61L27/50; A61L27/56; C03C11/00; C03C3/00; C03C3/04; C03C3/076; C03C3/078; C03C3/097
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
76 words
A dental or surgical implant having a surface for bonding to the bone of a recipient, said bonding surface comprising a biologically compatible glass, glass-ceramic or ceramic material comprising at least about 80 weight percent silicon dioxide and having a specific surface area of at least about 80 square meters per gram, a porosity of from about 10 to about 50 volume percent, and an average pore diameter of from about 20 to about 300 Angstroms.
Claim 2
Dependent Claim
76 words
A dental or surgical implant having a surface for bonding to the bone of a recipient, said bonding surface comprising a biologically compatible glass, glass-ceramic or ceramic material comprising at least about 80 weight percent silicon dioxide and having a specific surface area of at least about 80 square meters per gram, a porosity of from about 10 to about 50 volume percent, and an average pore diameter of from about 20 to about 300 Angstroms.
Claim 3
Dependent Claim
24 words
An implant of claim 1 wherein said material contains less than about 1 weight percent calcium and less than about 0.1 weight percent phosphorus.
Claim 4
Dependent Claim
17 words
An implant of claim 2 wherein said material comprises at least about 95 weight percent silicon dioxide.
Claim 5
Dependent Claim
17 words
An implant of claim 1 wherein said material comprises up to about 20 weight percent boron oxide.
Claim 6
Dependent Claim
11 words
An implant of claim 4 wherein said material is a glass.
Claim 7
Dependent Claim
87 words
A dental or surgical implant having a surface for bonding to the bone of a recipient, said bonding surface comprising a biologically compatible inorganic material capable of developing a porous silica-rich surface layer having a specific surface area of at least about 80 square meters per gram within about ten days' exposure to aqueous tris(hydroxymethyl)aminomethane buffer at a pH of 7.2 and a temperature of 37° C., said material being other than a silicon dioxide--based glass or glass-ceramic containing less than about 80 weight percent silicon dioxide.
Claim 8
Dependent Claim
87 words
A dental or surgical implant having a surface for bonding to the bone of a recipient, said bonding surface comprising a biologically compatible inorganic material capable of developing a porous silica-rich surface layer having a specific surface area of at least about 80 square meters per gram within about ten days' exposure to aqueous tris(hydroxymethyl)aminomethane buffer at a pH of 7.2 and a temperature of 37° C., said material being other than a silicon dioxide--based glass or glass-ceramic containing less than about 80 weight percent silicon dioxide.
Claim 9
Dependent Claim
13 words
An implant of claim 6 wherein said material is a hardened inorganic cement.
Claim 10
Dependent Claim
12 words
An implant of claim 7 wherein said cement is hardened Portland cement.
Claim 11
Dependent Claim
11 words
An implant of claim 6 wherein said material is a ceramic.
Claim 12
Dependent Claim
90 words
In a process for the fixation of a dental or surgical implant to bone comprising placing a wet cement between the surfaces of bone and implant and allowing said cement to harden, the improvement which comprises using a biologically compatible inorganic cement which, in the hardened state, is capable of developing a porous silica-rich surface layer having a specific surface area of at least about 80 square meters per gram within about ten days' exposure to aqueous tris(hydroxymethyl)aminomethane buffer at a pH of 7.2 and a temperature of 37° C.
Claim 13
Dependent Claim
90 words
In a process for the fixation of a dental or surgical implant to bone comprising placing a wet cement between the surfaces of bone and implant and allowing said cement to harden, the improvement which comprises using a biologically compatible inorganic cement which, in the hardened state, is capable of developing a porous silica-rich surface layer having a specific surface area of at least about 80 square meters per gram within about ten days' exposure to aqueous tris(hydroxymethyl)aminomethane buffer at a pH of 7.2 and a temperature of 37° C.
Claim 14
Dependent Claim
11 words
The improvement of claim 10 wherein said cement is Portland cement.
Claim 15
Dependent Claim
22 words
The improvement of claim 10 wherein said wet cement is mixed with particles of a biologically active silicon dioxide--based glass or glass-ceramic.
Claim 16
Dependent Claim
27 words
The improvement of claim 10 wherein the bonding surface of said implant in contact with said cement comprises a biologically active silicon dioxide--based glass or glass-ceramic material.
References Cited (Backward Citations)
US3054221A
Cited
US3147127A
Cited
US3804647A
Cited
US3923533A
Cited
US3908201A
Cited
US3922155A
Cited
US3987499A
Cited
GB1477899A
Cited
US3919723A
Cited
US4039339A
Cited
US4031571A
Cited
GB1505815A
Cited
US4056399A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-22 | 1983-04-23 | 1983-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-22 | 1987-04-23 | 1987-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-22 | 1991-04-23 | 1991-10-23 | $7700.00 | Window Closed / Lapsed |