7β-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins

Claim 1

A compound of the formula ##STR180## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, aluminum, alkali metal, alkaline earth metal, phenyl-lower alkylamine, N,N-dibenzylethylenediamine, lower alkylamines, triethylamine, or N-lower alkylpiperidines; R 1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl of up to 7 carbons, phenyl, phenyl-lower alkyl, substituted phenyl wherein said phenyl substituent is one or two members selected from the group consisting of halogen, lower alkyl, lower alkoxy, and hydroxy, or a heterocyclic selected from the group consisting of 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyridyl, 3-pyridyl, 4-pyridyl and 2-aminothiazolyl; R 2 is hydrogen or methoxy; R 3 is hydrogen, lower alkyl or phenyl-lower alkyl; R 4 is lower alkyl, cycloalkyl of up to 7 carbons, phenyl, substituted phenyl wherein the phenyl substituent is as defined above, or a heterocyclic selected from the group consisting of thienyl, furyl, pyridyl, thiazolyl and isothiazolyl; and X is hydrogen, lower alkanoyloxy, ##STR181## carbamoyloxy, lower alkoxy, lower alkylthio, or a heterothio group selected from the group consisting of ##STR182## and R 5 is hydrogen or lower alkyl.