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US4169142A
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Disaccharide analogs of antitumor anthracyclines, process for their preparation and use thereof
Assignee: Pfizer Italia SRL
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Filing: 1977-11-14
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Granted: 1979-09-25
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Expires: 1997-11-14
Abstract
Abstract Anthracycline disaccharides having antitumor activity are prepared by condensing N-trifluoroacetyldaunomycin with a 1-halosugar in the presence of a silver salt such as AgSO3CF3 as catalyst to form a protected di-glycoside which upon mild alkaline hydrolysis yields the novel disaccharides.
Inventors
- 👤 Sergio Penco
- 👤 Giuliano Franchi
- 👤 Federico Arcamone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:41
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
44 words
A compound of the formula: ##STR3## wherein R' and R 2 are H, OH or NH 2 and R 3 and R 4 are H or OH, provided that when R 2 is NH 2 , R 4 is H, and the hydrochlorides thereof.
Claim 2
Dependent Claim
44 words
A compound of the formula: ##STR3## wherein R' and R 2 are H, OH or NH 2 and R 3 and R 4 are H or OH, provided that when R 2 is NH 2 , R 4 is H, and the hydrochlorides thereof.
Claim 3
Dependent Claim
13 words
A compound according to claim 1, which is C-4'-(4"-epi)daunosaminyldaunomycin and the hydrochloride thereof.
Claim 4
Dependent Claim
13 words
A compound according to claim 1, which is C-4'-(2,6-dideoxy-α-L-arabinohexopyranosyl)daunomycin and the hydrochloride thereof.
Claim 5
Dependent Claim
31 words
A compound of the formula: ##STR4## wherein R 6 and R 7 are H, NHCOCF 3 or ---- p-nitrobenzoyl and R 8 and R 9 are H, OCOCF 3 or p-nitrobenzoyl.
Claim 6
Dependent Claim
31 words
A compound of the formula: ##STR4## wherein R 6 and R 7 are H, NHCOCF 3 or ---- p-nitrobenzoyl and R 8 and R 9 are H, OCOCF 3 or p-nitrobenzoyl.
Claim 7
Dependent Claim
31 words
A composition for inhibiting the growth of lymphocytic leukemia P 388 comprising a compound according to claim 1 in an amount sufficient to inhibit the growth thereof and a carrier therefor.
Claim 8
Dependent Claim
34 words
A method of inhibiting the growth of lymphocytic leukemia P 388 which comprises administering to a host afflicted therewith, a compound according to claim 1 in an amount sufficient in inhibit the growth thereof.
Claim 9
Dependent Claim
12 words
A method according to claim 6, wherein said compound is administered intraperitoneally.
References Cited (Backward Citations)
US3686163A
Cited
DE2548087A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-09-24 | 1983-03-26 | 1983-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-09-24 | 1987-03-26 | 1987-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-09-24 | 1991-03-26 | 1991-09-25 | $7700.00 | Window Closed / Lapsed |