Patent US4169069A successfully refreshed from Google Patents.
US4169069A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Silicon dioxide-containing compositions and process for their preparation and use
Assignee: Merck Patent GmbH
•
Filing: 1977-09-16
•
Granted: 1979-09-25
•
Expires: 1997-09-16
Abstract
Abstract A process for the incorporation of active materials into silicon dioxide-containing carrier materials, comprises encapsulating the active material with liquid polyalkoxysiloxane, polyorganoalkoxysiloxane or a mixture thereof and subsequently effecting hydrolytic polycondensation of the siloxane. The resultant enveloped active material has readily controllable release properties.
Inventors
- 👤 Klaus Unger
- 👤 Horst Kramer
- 👤 Herbert Rupprecht
- 👤 Wolfgang Kircher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:53
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1611; A01; A01N; A01N25/00; A01N25/08; A01N25/26; A01N25/28; A61K9/1629; A61K9/1641; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5031; B; B01; B01J; B01J13/00; B01J13/02; B01J13/06; B01J13/14; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
74 words
A process for the incorporation of an active material into a silicon dioxide-containing carrier material, which comprises encapsulating the active material with liquid polyalkoxysiloxane, polyorgano-alkoxysiloxane or a mixture thereof by dissolving, suspending, emulsifying or dispersing the active material in the liquid siloxane to achieve a uniform distribution of the active material particles in the siloxane; and subsequently effecting hydrolytic polycondensation of the siloxane, whereby the active material is uniformly distributed in the composition produced.
Claim 2
Dependent Claim
74 words
A process for the incorporation of an active material into a silicon dioxide-containing carrier material, which comprises encapsulating the active material with liquid polyalkoxysiloxane, polyorgano-alkoxysiloxane or a mixture thereof by dissolving, suspending, emulsifying or dispersing the active material in the liquid siloxane to achieve a uniform distribution of the active material particles in the siloxane; and subsequently effecting hydrolytic polycondensation of the siloxane, whereby the active material is uniformly distributed in the composition produced.
Claim 3
Dependent Claim
19 words
The process of claim 1, wherein the alkoxy groups of polyalkoxysiloxane and the polyorganoalkoxysiloxane possess 1 to 4 C-atoms.
Claim 4
Dependent Claim
22 words
The process of claim 1, wherein the hydrolytic polycondensation is carried out by addition of gaseous water and gaseous NH 3 .
Claim 5
Dependent Claim
27 words
The process of claim 1, wherein the hydrolytic polycondensation is carried out so that the resultant enveloping layer possesses a thickness of about 1 to 120 μm.
Claim 6
Dependent Claim
28 words
The process of claim 1, wherein the hydrolytic polycondensation is carried out so that the pore diameter of the resultant enveloping layer is about 20 to 400 A.
Claim 7
Dependent Claim
25 words
The process of claim 1 which comprises dispersing the active material in liquid polyalkoxysiloxane, polyorganoalkoxysiloxane or a mixture thereof and subsequently hydrolytically polycondensing the siloxane.
Claim 8
Dependent Claim
19 words
The process of claim 1, wherein the encapsulating takes place in the presence of a solvent for the siloxane.
Claim 9
Dependent Claim
32 words
The process of claim 1, which comprises suspending the active material in liquid polyalkoxysiloxane, polyorganoalkoxysiloxane or a mixture thereof and dispersing the resultant suspension with stirring in water containing a polycondensation catalyst.
Claim 10
Dependent Claim
20 words
A composition comprising an active material and a silicon dioxide-containing carrier which is prepared by the process of claim 1.
Claim 11
Dependent Claim
24 words
A method of administering an active material with controlled release properties which comprises administering the active ingredient as a composition according to claim 9.
Claim 12
Dependent Claim
116 words
A process for incorporation of particles of an active material attached to a first carrier into a silicon dioxide-containing carrier material, which comprises encapsulating the particles of active material attached to the first carrier with liquid polyalkoxysiloxane, polyorgano-alkoxysiloxane or a mixture thereof by suspending or dispersing the particles of active material attached to the first carrier in the absence of water in the liquid siloxane or a solution thereof; when a solution is used, subsequently evaporating the solvent to achieve a uniform coating of the active material particles with the siloxane; and then hydrolytically polycondensing the siloxane whereby the particles of the active material attached to the first carrier are uniformly distributed in the composition produced.
Claim 13
Dependent Claim
116 words
A process for incorporation of particles of an active material attached to a first carrier into a silicon dioxide-containing carrier material, which comprises encapsulating the particles of active material attached to the first carrier with liquid polyalkoxysiloxane, polyorgano-alkoxysiloxane or a mixture thereof by suspending or dispersing the particles of active material attached to the first carrier in the absence of water in the liquid siloxane or a solution thereof; when a solution is used, subsequently evaporating the solvent to achieve a uniform coating of the active material particles with the siloxane; and then hydrolytically polycondensing the siloxane whereby the particles of the active material attached to the first carrier are uniformly distributed in the composition produced.
Claim 14
Dependent Claim
13 words
The process of claim 11, wherein the carrier is porous, spheroidal silica gel.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-09-24 | 1983-03-26 | 1983-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-09-24 | 1987-03-26 | 1987-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-09-24 | 1991-03-26 | 1991-09-25 | $7700.00 | Window Closed / Lapsed |