US4168312A
Expired / Lapsed
US
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Quinolone derivatives
Assignee: Merck Patent GmbH
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Filing: 1977-11-08
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Granted: 1979-09-18
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Expires: 1997-11-08
Abstract
Abstract New quinolone derivatives of the Formula I ##STR1## wherein R 1 and R 2 are each H, F, Cl, Br, CF 3 or CH 3 O or a physiologically acceptable acid addition salt thereof possess pharmacological properties including thrombocyte aggregation inhibiting action.
Inventors
- 👤 Erich Schacht
- 👤 Hans Dahm
- 👤 Reinhard Lissner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:51
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/22; A; A61; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
50 words
a pharmaceutical composition in table, capsule or dragee form which comprises, in admixture with a pharmaceutically acceptable adjuvant, an amount effective to inhibit thrombocyte aggregation of a compound of the formula ##STR5## wherein R 1 and R 2 are each H, F, Cl, Br, CF 3 or CH 3 O.
Claim 2
Dependent Claim
50 words
a pharmaceutical composition in table, capsule or dragee form which comprises, in admixture with a pharmaceutically acceptable adjuvant, an amount effective to inhibit thrombocyte aggregation of a compound of the formula ##STR5## wherein R 1 and R 2 are each H, F, Cl, Br, CF 3 or CH 3 O.
Claim 3
Dependent Claim
10 words
The composition of claim 1 wherein R 1 is H.
Claim 4
Dependent Claim
13 words
A composition of claim 1 wherein, R 1 is Cl in the 6-position.
Claim 5
Dependent Claim
12 words
The composition of claim 1 wherein R 2 is CH 3 O.
Claim 6
Dependent Claim
12 words
The composition of claim 4 wherein R 2 is in the 4-position.
Claim 7
Dependent Claim
11 words
The composition of claim 1 wherein the compound therein is 1-p-methoxyphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one.
Claim 8
Dependent Claim
17 words
A compound selected from the group consisting of 1-o-methoxyphenyl-4-acetoxy-1,2-dihydro-quinoline-2-one; 1-m-methoxyphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one; 1-p-methoxyphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one; 1-o-trifluoromethylphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one; 1-m-trifluoromethylphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one; 1-p-trifluoromethylphenyl-4-acetoxy-1,2-dihydro-quinolin--2-one; 1-m-trifluoromethylphenyl-4-acetoxy-6-chloro-1,2-dihydro-quinolin-2-one; and 1-p-methoxyphenyl-4-acetoxy-6-chloro-1,2-dihydro-quinolin-2-one.
Claim 9
Dependent Claim
17 words
A compound selected from the group consisting of 1-o-methoxyphenyl-4-acetoxy-1,2-dihydro-quinoline-2-one; 1-m-methoxyphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one; 1-p-methoxyphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one; 1-o-trifluoromethylphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one; 1-m-trifluoromethylphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one; 1-p-trifluoromethylphenyl-4-acetoxy-1,2-dihydro-quinolin--2-one; 1-m-trifluoromethylphenyl-4-acetoxy-6-chloro-1,2-dihydro-quinolin-2-one; and 1-p-methoxyphenyl-4-acetoxy-6-chloro-1,2-dihydro-quinolin-2-one.
Claim 10
Dependent Claim
6 words
1-p-methoxyphenyl-4-acetoxy-1,2-dihydro-quinolin-2-one, a compound of claim 7.
Claim 11
Independent Claim
45 words
A method of inhibiting thrombocyte aggregation in mammals which comprises administering systemically thereto an amount of a compound of the formula ##STR6## wherein R 1 and R 2 are each H, F, Cl, Br, CF 3 or CH 3 O, effective to inhibit thrombocyte aggregation.
Claim 12
Independent Claim
45 words
A method of inhibiting thrombocyte aggregation in mammals which comprises administering systemically thereto an amount of a compound of the formula ##STR6## wherein R 1 and R 2 are each H, F, Cl, Br, CF 3 or CH 3 O, effective to inhibit thrombocyte aggregation.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-09-17 | 1983-03-19 | 1983-09-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-09-17 | 1987-03-19 | 1987-09-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-09-17 | 1991-03-19 | 1991-09-18 | $7700.00 | Window Closed / Lapsed |