Alkanolamine derivatives and pharmaceutical compositions and uses thereof

Claim 1

A pharmaceutical composition comprising as active ingredient a therapeutically effective amount of at least one alkanolamine selected from compounds of the formula: ##STR20## wherein A is alkylene of from 2 to 12 carbon atoms, wherein R 1 is hydrogen, or alkyl, halogenoalkyl, alkenyl or cycloalkyl each of up to 10 carbon atoms, or aryl of the formula: ##STR21## wherein R 2 , R 3 , R 12 and R 13 , which may be the same or different, each is hydrogen, halogen, hydroxy, amino, nitro or cyano, alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, cycloalkoxy, alkenyloxy, alkynyloxy or alkanoyl each of up to 6 carbon atoms, or aryl, aryloxy or aralkoxy each of up to 12 carbon atoms; or wherein R 2 and R 3 together, and/or R 12 and R 13 together, are trimethylene, tetramethylene, 1-oxotetramethylene, propenylene, but-2-enylene or buta-1,3-dienylene such that together with the adjacent benzene ring they form respectively indanyl, 5,6,7,8-tetrahydronaphthyl, 5-oxo-5,6,7,8-tetrahydronaphthyl, indenyl, 5,8-dihydronaphthyl or naphthyl; wherein R 4 is hydrogen, hydroxy or hydroxymethyl or aralkoxy of up to 12 carbon atoms; wherein R 14 is hydrogen, amino or dialkylamino of up to 12 carbon atoms; wherein X is carbonyl (--CO--) and wherein Y is a direct link, or alkylene, oxyalkylene or alkyleneoxy each of up to 6 carbon atoms, or except when R 1 is hydrogen, oxygen; and the acid-addition salts thereof, in association with a pharmaceutically-acceptable diluent or carrier therefor.