US3961072A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenoxypropanolamine therapeutic agents
Assignee: Pfizer Inc
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Filing: 1974-08-09
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Granted: 1976-06-01
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Expires: 1994-08-09
Abstract
Abstract A series of novel substituted phenoxypropylamine derivatives have been prepared by reacting the appropriate 1-phenoxy-2,3-epoxypropane compound with a suitable organic amine reagent. The resulting 1-phenoxy-3-alkylaminopropan-2-ols are useful in the field of chemotherapy as anti-angina agents. Preferred members include compounds having an acetamido group substituted on the phenyl ring of the phenoxy moiety. Alternate methods of preparation are also provided.
Inventors
- 👤 David Alexander Cox
- 👤 John Christopher Danilewicz
- 👤 Allan Leslie Ham
- 👤 John Edward Glyn Kemp
- 👤 Michael Snarey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:49
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/13; A61K31/135; C; C07; C07C; C07C233/00; C07C233/01; C07C233/16
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
114 words
A method for effecting anti-anginal action in the treatment of a cardiac-afflicted subject, which comprises administering to said subject an effective anti-anginal amount of a compound selected from the group consisting of phenoxypropanolamine bases of the formula: ##EQU2## and the pharmaceutically acceptable acid addition salts thereof, wherein R of R(CH 2 ) n is alkanoylamino having from one to six carbon atoms when n is zero and is alkanoylamino having from one to three carbon atoms when n is one, said n being an integer of from 0 to 1, inclusive; R 1 is hydrogen, allyl or methyl, and R 4 is alkanoylaminophenoxyethyl having from one to six carbon atoms in the alkanoyl moiety.
Claim 2
Independent Claim
114 words
A method for effecting anti-anginal action in the treatment of a cardiac-afflicted subject, which comprises administering to said subject an effective anti-anginal amount of a compound selected from the group consisting of phenoxypropanolamine bases of the formula: ##EQU2## and the pharmaceutically acceptable acid addition salts thereof, wherein R of R(CH 2 ) n is alkanoylamino having from one to six carbon atoms when n is zero and is alkanoylamino having from one to three carbon atoms when n is one, said n being an integer of from 0 to 1, inclusive; R 1 is hydrogen, allyl or methyl, and R 4 is alkanoylaminophenoxyethyl having from one to six carbon atoms in the alkanoyl moiety.
Claim 3
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is 1-(4-acetamidophenoxy)-3-[2-(4-acetamidophenoxy)ethylamino]propan-2ol.
Claim 4
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is 1-(4-acetamidomethylphenoxy)-3-[2-(4-acetamidophenoxy)ethylamino]propan-2-ol.
Claim 5
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is 1-(2-methyl-4-acetamidophenoxy)-3-[2-(4-acetamidophenoxy)ethylamino]propan-2-ol.
Claim 6
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is 1-(2-methyl-4-acetamidomethylphenoxy)-3-[2-(4-acetamidophenoxy)ethylamino]propan-2-ol.
Claim 7
Dependent Claim
13 words
The method as claimed in claim 1 wherein the compound administered is 1-(2-allyl-4-acetamidophenoxy)-3-[2-(4-acetamidophenoxy)ethylamino]propan-2-ol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |