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US4166907A
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3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity
Assignee: ER Squibb and Sons LLC
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Filing: 1977-10-11
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Granted: 1979-09-04
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Expires: 1997-10-11
Abstract
Abstract Compounds having the formula <IMAGE> wherein R1 is alkyl, cycloalkyl or aryl; R2 is dialkylamino or a nitrogen containing heterocyclic group; A1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A2 is an alkylene group having 2 to 5 carbon atoms; have antiinflammatory activity.
Inventors
- 👤 John Krapcho
- 👤 Chester F. Turk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 08:31
CPC Classifications
C; C07; C07D; C07D205/00; C07D205/02; C07D205/06; C07D205/08
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
91 words
A compound having the formula ##STR5## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, cycloalkyl, phenyl, or phenyl substituted with a halogen, alkyl, alkoxy, trifluoromethyl, or nitro group; R 2 is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl or 4-alkyl-1-piperazinyl; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; A 2 is an alkylene group having 2 to 5 carbon atoms; wherein alkyl and alkoxy are groups having 1 to 6 carbon atoms; and cycloalkyl is a group having 3 to 7 carbon atoms.
Claim 2
Dependent Claim
91 words
A compound having the formula ##STR5## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, cycloalkyl, phenyl, or phenyl substituted with a halogen, alkyl, alkoxy, trifluoromethyl, or nitro group; R 2 is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl or 4-alkyl-1-piperazinyl; A 1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; A 2 is an alkylene group having 2 to 5 carbon atoms; wherein alkyl and alkoxy are groups having 1 to 6 carbon atoms; and cycloalkyl is a group having 3 to 7 carbon atoms.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is alkyl.
Claim 4
Dependent Claim
24 words
A compound in accordance with claim 1 wherein R 1 is phenyl or phenyl substituted with a halogen, alkyl, alkoxy, trifluoromethyl or nitro group.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 3 wherein R 1 is phenyl.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 2 is 4-morpholinyl.
Claim 7
Dependent Claim
14 words
The compound in accordance with claim 5 having the name 3,3-dichloro-4-[2-[3-(4-morpholinyl)propoxy]phenyl]-1-(2-phenylethyl)-2-azetidinone, hydrochloride salt (1:1).
References Cited (Backward Citations)
US3194801A
Cited
US3481920A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-09-03 | 1983-03-05 | 1983-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-09-03 | 1987-03-05 | 1987-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-09-03 | 1991-03-05 | 1991-09-04 | $7700.00 | Window Closed / Lapsed |