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US4166106A
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Immunologic determination method
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1977-09-22
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Granted: 1979-08-28
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Expires: 1997-09-22
Abstract
Abstract A method for determininng a reagent capable of immunologic reaction by direct or indirect test methods, wherein an antigen is contacted with the Fc fragment of an immune globulin prior to contacting it with an antibody having no specificity to said Fc fragment, whereby unspecific linkages arre decreased.
Inventors
- 👤 Hans-Harald Sedlacek
- 👤 Roloff Johannsen
- 👤 Friedrich-Robert Seiler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:43
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/563; G01N2474/00; G01N2474/20; Y; Y10; Y10S; Y10S435/00; Y10S435/962; Y10S436/00; Y10S436/80; Y10S436/805
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
55 words
In a method for determining a reagent capable of immunologic reaction, which method includes an affinity reaction between an antigen and an antibody, the improvement wherein said antigen is contacted with the Fc fragment of an immune globulin prior to contacting it with said antibody, and said antibody has no specificity to said Fc fragment.
Claim 2
Dependent Claim
55 words
In a method for determining a reagent capable of immunologic reaction, which method includes an affinity reaction between an antigen and an antibody, the improvement wherein said antigen is contacted with the Fc fragment of an immune globulin prior to contacting it with said antibody, and said antibody has no specificity to said Fc fragment.
Claim 3
Dependent Claim
24 words
A method as in claim 1 wherein an amount of Fc fragment equivalent to the amount of Fc receptors on said antigen is used.
Claim 4
Dependent Claim
24 words
A method as in claim 1 wherein said Fc fragment is obtained by enzymatic cleavage of an immune globulin with papain, plasmin, or pepsin.
Claim 5
Dependent Claim
13 words
A method as in claim 1, wherein an antibody in solution is determined.
Claim 6
Dependent Claim
26 words
A method as in claim 1 wherein an antigen present in cytoplasm, in a cell membrane, in a cell nucleus, or in a tissue is determined.
Claim 7
Dependent Claim
16 words
A method as in claim 5 wherein an antigen in mixed lymphocyte culture determinants is determined.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-27 | 1983-02-26 | 1983-08-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-27 | 1987-02-26 | 1987-08-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-27 | 1991-02-26 | 1991-08-28 | $7700.00 | Window Closed / Lapsed |