US4165429A
Expired / Lapsed
US
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7α-METHOXY-CEPHALOSPORANIC ACID DERIVATIVES
Assignee: Astellas Pharma Inc
•
Filing: 1977-06-15
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Granted: 1979-08-21
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Expires: 1997-06-15
Abstract
Abstract Novel 7 alpha -methoxy-7 beta -heterocyclic thioacetamido-3-heterocyclic thiomethyl- DELTA 3-cephem-4-carboxylic acid derivatives and pharmaceutically acceptable salts thereof. These compounds show high antibiotic activities against various microorganisms including gram positive and negative bacteria.
Inventors
- 👤 Masaru Iwanami
- 👤 Masuo Murakami
- 👤 Yoshinobu Nagano
- 👤 Masaharu Fujimoto
- 👤 Tetsuya Maeda
- 👤 Noriaki Nagano
- 👤 Atsuki Yamazaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 04:57
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/57
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
107 words
The 7α-methoxy-7β-heterocyclic thioacetamido-3-heterocyclic thiomethyl-Δ 3 -cephem-4-carboxylic acid represented by the formula and the pharmaceutically acceptable salts thereof wherein R 1 is ##STR33## wherein R 5 represents a hydroxy group, an amino group, a mercapto group, a lower alkylamino group having 1 to 4 carbon atoms, a lower alkanoylamino group having 1 to 4 carbon atoms, a lower alkoxycarbonylamino group having 1 to 4 carbon atoms in the alkoxy moiety, a carboxy lower alkylthio group having 1 to 4 carbon atoms in the alkyl moiety, or a 3-lower alkylureido group having 1 to 4 carbon atoms in the alkyl moiety; and R 2 is a 5-lower alkyl-1,3,4-thiadiazol-2-yl group.
Claim 2
Dependent Claim
107 words
The 7α-methoxy-7β-heterocyclic thioacetamido-3-heterocyclic thiomethyl-Δ 3 -cephem-4-carboxylic acid represented by the formula and the pharmaceutically acceptable salts thereof wherein R 1 is ##STR33## wherein R 5 represents a hydroxy group, an amino group, a mercapto group, a lower alkylamino group having 1 to 4 carbon atoms, a lower alkanoylamino group having 1 to 4 carbon atoms, a lower alkoxycarbonylamino group having 1 to 4 carbon atoms in the alkoxy moiety, a carboxy lower alkylthio group having 1 to 4 carbon atoms in the alkyl moiety, or a 3-lower alkylureido group having 1 to 4 carbon atoms in the alkyl moiety; and R 2 is a 5-lower alkyl-1,3,4-thiadiazol-2-yl group.
Claim 3
Dependent Claim
108 words
The 7α-methoxy-7β-heterocyclic thioacetamido-3-heterocyclic thiomethyl-Δ 3 -cephem-4-carboxylic acid represented by the formula ##STR34## and the pharmaceutically acceptable salts thereof wherein R 1 is ##STR35## wherein R 5 represents a hydroxy group, an amino group, a mercapto group, a lower alkylamino group having 1 to 4 carbon atoms, a lower alkanoylamino group having 1 to 4 carbon atoms, a lower alkoxycarbonylamino group having 1 to 4 carbon atoms in the alkoxy moiety, a carboxy lower alkylthio group having 1 to 4 carbon atoms in the alkyl moiety, or a 3-lower alkylureido group having 1 to 4 carbon atoms in the alkyl moiety; and R 2 is a 1-lower alkyl-tetrazol-5-yl group.
Claim 4
Dependent Claim
108 words
The 7α-methoxy-7β-heterocyclic thioacetamido-3-heterocyclic thiomethyl-Δ 3 -cephem-4-carboxylic acid represented by the formula ##STR34## and the pharmaceutically acceptable salts thereof wherein R 1 is ##STR35## wherein R 5 represents a hydroxy group, an amino group, a mercapto group, a lower alkylamino group having 1 to 4 carbon atoms, a lower alkanoylamino group having 1 to 4 carbon atoms, a lower alkoxycarbonylamino group having 1 to 4 carbon atoms in the alkoxy moiety, a carboxy lower alkylthio group having 1 to 4 carbon atoms in the alkyl moiety, or a 3-lower alkylureido group having 1 to 4 carbon atoms in the alkyl moiety; and R 2 is a 1-lower alkyl-tetrazol-5-yl group.
Claim 5
Dependent Claim
4 words
7β-(5-Amino-1,3,4-thiadiazol-5-yl)thioacetamido-7α-methoxy-3-(1-methyltetrazol-5-yl)thiomethyl-Δ 3 -cephem-4-carboxylic acid.
Claim 6
Dependent Claim
4 words
7β-(5-Amino-1,3,4-thiadiazol-5-yl)thioacetamido-7α-methoxy-3-(1-methyltetrazol-5-yl)thiomethyl-Δ 3 -cephem-4-carboxylic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-20 | 1983-02-19 | 1983-08-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-20 | 1987-02-19 | 1987-08-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-20 | 1991-02-19 | 1991-08-21 | $7700.00 | Window Closed / Lapsed |