US3887549A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing 7-acylamido-7-methoxy-3-cephem-4-carboxylic acid, esters and salts
Assignee: Merck and Co Inc
•
Filing: 1972-04-12
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Granted: 1975-06-03
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Expires: 1992-04-12
Abstract
Abstract Process for preparing 7-acylamido-7-methoxy-3-cephem-4carboxylic acid and its corresponding esters and salts which comprises treating the corresponding 7-acylamido-7-methoxy-2cephem-4-carboxylic acid compound with an isomerizing agent. The products are useful as antibiotics.
Inventors
- 👤 Burton G Christensen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 13:16
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6561; C07F9/65613
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
9 words
THE PROCESS FOR PREPARING A COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
9 words
THE PROCESS FOR PREPARING A COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
9 words
The process for preparing a compound of the formula:
Claim 4
Dependent Claim
9 words
The process for preparing a compound of the formula:
Claim 5
Dependent Claim
55 words
The process according to claim 1 wherein A is hydrogen, lower alkanoyloxy, carbamoyloxy or pyridine; R1 is hydrogen or trichloroethyl, tert-butyl, benzoylmethyl, p-methoxybenzyl, benzyl, benzhydryl, trimethylsilyl or methoxymethyl; R2 is hydrogen, amino or carboxy; and R3 is phenyl or a 5- or 6-membered heterocyclic ring containing from 1 to 2 sulfur, oxygen or nitrogen atoms.
Claim 6
Dependent Claim
27 words
The process according to claim 1 wherein A is hydrogen, acetoxy, carbamoyloxy or pyridyl; R1 is hydrogen, trichloroethyl, tert-butyl, benZoylmethyl, p-methoxybenzyl, benzyl, benzhydryl, trimethylsilyl or methoxymethyl; R2R3
Claim 7
Dependent Claim
29 words
The process according to claim 1 wherein the inorganic bases are selected from the group consisting of sodium carbonate, potassium carbonate, sodium hydroxide, calcium hydroxide, alumina and silica gel.
Claim 8
Dependent Claim
21 words
The process according to claim 4 for preparing methoxy methyl ester of 3-carbamoyloxymethyl-7-(2-thienylacetamido)-7-methoxy-3-cephem-4-carboxylic acid from the methoxymethyl ester of 3-carbamoyloxymethyl-7-(2-thienylacetamido)-7-methoxy-2-cephem-4-carboxylic acid.
Claim 9
Dependent Claim
21 words
The process according to claim 4 for preparing the dibenzhydryl ester of 3-carbamoyloxymethyl-7-phenylmalonamido-7-methoxy-3-cephem-4-carboxylic acid from the dibenzhydryl ester of 3-carbamoyloxymethyl-7-phenylmalonamido-7-methoxy-2-cephem-4-carboxylic acid.
Claim 10
Dependent Claim
21 words
The process according to claim 4 for preparing the benzhydryl ester of 3-carbamoyloxymethyl-7-(2-furylacetamido)-7-methoxy-3-cephem-4-carboxylic acid from the benzhydryl ester of 3-carbamoyloxymethyl-7-(2-furylacetamido)-7-methoxy-2-cephem-4-carboxylic acid.
Claim 11
Dependent Claim
9 words
A process for preparing a compound of the formula:
Claim 12
Dependent Claim
9 words
A process for preparing a compound of the formula:
Claim 13
Dependent Claim
16 words
The process according to claim 8 for preparing 7-methoxy-7-(2-thienylacetylamido)-3-carbamoyloxymethyl-3-cephem-4 -carboxylic acid or a sodium salt thereof.
Claim 14
Dependent Claim
19 words
The process according to claim 8 for preparing 7-methoxy-7-( Alpha -amino- Alpha -phenylacetamido)-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid or a sodium salt thereof.
Claim 15
Dependent Claim
17 words
The process according to claim 8 for preparing 7-methoxy-7-( Alpha -carboxyphenylacetamido)-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid or a sodium salt thereof.
Claim 16
Dependent Claim
15 words
The process according to claim 8 for preparing 7-methoxy-7-(phenylmalonamido)-3-carBamoyloxymethyl-3-cephem-4-carboxylic acid or a sodium salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-06-02 | 1978-12-02 | 1979-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-06-02 | 1982-12-02 | 1983-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-06-02 | 1986-12-02 | 1987-06-03 | $7700.00 | Window Closed / Lapsed |