US4165320A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Amino acid derivatives
Assignee: ER Squibb and Sons LLC
•
Filing: 1978-06-29
•
Granted: 1979-08-21
•
Expires: 1998-06-29
Abstract
Abstract New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Miguel A. Ondetti
- 👤 Michael E. Condon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 01:16
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/86; C07C; C07C327/00; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D207/46; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20; C07D211/06; C07D211/36; C07D211/60; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
68 words
A compound of the formula ##STR13## and salts thereof, wherein R is hydroxy or lower alkoxy R 1 is hydrogen, lower alkanoyl or amino (imino)methyl; R 2 is hydrogen, lower alkyl or phenyl-lower alkylene; R 3 is hydrogen, lower alkanoyl, benzoyl or ##STR14## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is indolyl-lower alkylene; m is 1, 2, 3 or 4; and n is 0 or 1.
Claim 2
Dependent Claim
68 words
A compound of the formula ##STR13## and salts thereof, wherein R is hydroxy or lower alkoxy R 1 is hydrogen, lower alkanoyl or amino (imino)methyl; R 2 is hydrogen, lower alkyl or phenyl-lower alkylene; R 3 is hydrogen, lower alkanoyl, benzoyl or ##STR14## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is indolyl-lower alkylene; m is 1, 2, 3 or 4; and n is 0 or 1.
Claim 3
Dependent Claim
13 words
A compound as in claim 1 wherein ##STR15## is the radical of tryptophane.
Claim 4
Dependent Claim
53 words
A compound as in claim 1 wherein R is hydroxy; R 1 is hydrogen, lower alkanoyl, or amino(imino)methyl; R 2 is hydrogen, lower alkyl or phenyl-lower alkylene; R 3 is hydrogen, lower alkanoyl or benzoyl; A is hydrogen; B is indolyl-lower alkylene; m is 3 or 4 and n is 0 or 1.
Claim 5
Dependent Claim
11 words
A compound as in claim 1 wherein R 3 is ##STR16##
Claim 6
Dependent Claim
10 words
A compound as in claim 1 wherein R is hydroxy.
Claim 7
Dependent Claim
26 words
A compound as in claim 2 wherein R 1 and R 2 each is hydrogen, R 3 is acetyl, m is 3 and n is 1.
Claim 8
Dependent Claim
25 words
A compound as in claim 2 wherein, R 1 , R 2 and R 3 each is hydrogen, m is 3 and n is 1.
Claim 9
Dependent Claim
29 words
A compound as in claim 1 wherein R is hydroxy, R 2 and R 3 each is hydrogen, R 1 is amino(imino)methyl, m is 3 and n is 1.
Claim 10
Dependent Claim
28 words
A compound as in claim 4 wherein each R is hydroxy, each R 1 and R 2 is hydrogen, each m is 1 and each n is 1.
References Cited (Backward Citations)
US3180875A
Cited
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Cited
USB446107I5
Cited
US4001276A
Cited
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Cited
US4059583A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-20 | 1983-02-19 | 1983-08-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-20 | 1987-02-19 | 1987-08-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-20 | 1991-02-19 | 1991-08-21 | $7700.00 | Window Closed / Lapsed |