US4064235A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dopamine derivative compounds, preparation thereof and medicine containing same
Assignee: Eisai Co Ltd
•
Filing: 1976-08-17
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Granted: 1977-12-20
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Expires: 1996-08-17
Abstract
Abstract A novel dopamine derivative compound having the following general formula and pharmacologically acceptable acid addition salt thereof: ##STR1## wherein X stands for a di- or tri-peptide residue derived from alanine, glycine, glutamine, isoleucine, lysine, leucine, tyrosine proline or valine, having an excellent activity of increasing the renal blood flow are provided.
Inventors
- 👤 Noboru Yanaihara
- 👤 Toshiji Igarashi
- 👤 Youichi Kunii
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:09
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06034; C07K5/06026; C07K5/06052; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
34 words
A compound having the formula: ##STR8## wherein X is a di- or tri-peptide residue derived from alanine, glycine, glutamine, isoleucine, lysine, leucine, tyrosine, proline or valine, or a pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
34 words
A compound having the formula: ##STR8## wherein X is a di- or tri-peptide residue derived from alanine, glycine, glutamine, isoleucine, lysine, leucine, tyrosine, proline or valine, or a pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
15 words
A compound as claimed in claim 1 wherein the group ##STR9## is a glycyl-L-prolyl group.
Claim 4
Dependent Claim
15 words
A compound as claimed in claim 1 wherein the group ##STR10## is a L-isoleucylvalyl group.
Claim 5
Dependent Claim
15 words
A compound as claimed in claim 1 wherein the group ##STR11## is a glycyl-L-glutamyl group.
Claim 6
Dependent Claim
15 words
A compound as claimed in claim 1 wherein the group ##STR12## is a glycylglycyl-L-Leucyl group.
Claim 7
Dependent Claim
15 words
A compound as claimed in claim 1 wherein the group ##STR13## is a glycylglycyl-L-prolyl group.
Claim 8
Independent Claim
60 words
A method of increasing the renal blood flow rate in a subject requiring such treament, which comprises: administering to such subject a therapeutically effective amount of a compound having the formula: ##STR14## wherein X is a di- or tri-peptide residue derived from alanine, glycine, glutamine, isoleucine, lysine, leucine, tyrosine, proline or valine, or a pharmacologically acceptable acid addition salt thereof.
Claim 9
Independent Claim
60 words
A method of increasing the renal blood flow rate in a subject requiring such treament, which comprises: administering to such subject a therapeutically effective amount of a compound having the formula: ##STR14## wherein X is a di- or tri-peptide residue derived from alanine, glycine, glutamine, isoleucine, lysine, leucine, tyrosine, proline or valine, or a pharmacologically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
15 words
A method as claimed in claim 7 wherein the group ##STR15## is a glycyl-L-prolyl group.
Claim 11
Dependent Claim
15 words
A method as claimed in claim 7 wherein the group ##STR16## is an L-isoleucylvalyl group.
Claim 12
Dependent Claim
15 words
A method as claimed in claim 7 wherein the group ##STR17## is a glycyl-L-glutamyl group.
Claim 13
Dependent Claim
15 words
A method as claimed in claim 7 wherein the group ##STR18## is a glycylglycyl-L-leucyl group.
Claim 14
Dependent Claim
15 words
A method as claimed in claim 7 wherein the group ##STR19## is a glycylglycyl-L-prolyl group.
Claim 15
Dependent Claim
18 words
A method according to claim 7 in which said compound is administered in combination with a pharmaceutical carrier.
Claim 16
Dependent Claim
23 words
A method according to claim 7 in which the compound is administered in an amount of from 10 to 500 mg per day.
References Cited (Backward Citations)
US3803120A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-19 | 1981-06-20 | 1981-12-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-19 | 1985-06-20 | 1985-12-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-19 | 1989-06-20 | 1989-12-20 | $7700.00 | Window Closed / Lapsed |