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US4162323A
Expired / Lapsed
US
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Antibiotic N-acetyl-dehydro-thienamycin
Assignee: Merck and Co Inc
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Filing: 1977-04-18
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Granted: 1979-07-24
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Expires: 1997-04-18
Abstract
Abstract Antibiotic N-acetyl-dehydro-thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces in suitable fermentation media.
Inventors
- 👤 Jean S. Kahan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:24
CPC Classifications
C; C07; C07D; C07D477/00; C07D477/10; C07D477/12; C07D477/16; C07D477/20; A; A61; A61P; A61P31/00; A61P31/04; C12; C12P; C12P17/00; C12P17/18; C12P17/182; C12P17/184
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
81 words
The compound having the following structure: ##STR3## or its pharmaceutically acceptable salts wherein the compound has 300 MHz nuclear magnetic resonance characteristic signals having chemical shifts in ppm as 1.29 (d, J=6, CH 3 ); 2.08 ##STR4## 3.10 (d, d, J=12.5, 8.7, 1H of CH 2 C); 3.21 (d, d, J=12.5, 9.5, 1H of CH 2 C); 3.39 (d, d, J=6.0, 2.5, H 6 ); 4.22 (m, H 5 and H 7 ); 6.07 (d, J=13.5, HC═); 7.19 (d, J=13.5, HC═).
Claim 2
Dependent Claim
81 words
The compound having the following structure: ##STR3## or its pharmaceutically acceptable salts wherein the compound has 300 MHz nuclear magnetic resonance characteristic signals having chemical shifts in ppm as 1.29 (d, J=6, CH 3 ); 2.08 ##STR4## 3.10 (d, d, J=12.5, 8.7, 1H of CH 2 C); 3.21 (d, d, J=12.5, 9.5, 1H of CH 2 C); 3.39 (d, d, J=6.0, 2.5, H 6 ); 4.22 (m, H 5 and H 7 ); 6.07 (d, J=13.5, HC═); 7.19 (d, J=13.5, HC═).
Claim 3
Dependent Claim
96 words
A composition comprising an antibacterial effective amount of the compound having the following structure: ##STR5## or its pharmaceutically acceptable salts wherein the compound has 300 MHz nuclear magnetic resonance characteristic signals having chemical shifts in ppm as 1.29 (d, J=6, CH 3 ); 2.08 ##STR6## 3.10 (d, d, J=12.5, 8.7, 1H of CH 2 C); 3.21 (d, d, J=12.5, 9.5, 1H of CH 2 C); 3.39 (d, d, J=6.0, 2.5, H 6 ); 4.22 (m, H 5 and H 7 ); 6.07 (d, J=13.5, HC═); 7.19 (d, J=13.5, HC═) and a non-toxic pharmaceutically acceptable carrier therefore.
Claim 4
Dependent Claim
96 words
A composition comprising an antibacterial effective amount of the compound having the following structure: ##STR5## or its pharmaceutically acceptable salts wherein the compound has 300 MHz nuclear magnetic resonance characteristic signals having chemical shifts in ppm as 1.29 (d, J=6, CH 3 ); 2.08 ##STR6## 3.10 (d, d, J=12.5, 8.7, 1H of CH 2 C); 3.21 (d, d, J=12.5, 9.5, 1H of CH 2 C); 3.39 (d, d, J=6.0, 2.5, H 6 ); 4.22 (m, H 5 and H 7 ); 6.07 (d, J=13.5, HC═); 7.19 (d, J=13.5, HC═) and a non-toxic pharmaceutically acceptable carrier therefore.
References Cited (Backward Citations)
US3950357A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-07-23 | 1983-01-22 | 1983-07-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-07-23 | 1987-01-22 | 1987-07-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-07-23 | 1991-01-22 | 1991-07-24 | $7700.00 | Window Closed / Lapsed |