US4160024A
Expired / Lapsed
US
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Marek's disease vaccine
Assignee: Cornell Research Foundation Inc
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Filing: 1978-05-01
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Granted: 1979-07-03
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Expires: 1998-05-01
Abstract
Abstract A vaccine against Marek's disease is produced from a newly isolated Marek's disease virus which is unattenuated and naturally nononcogenic, even in immunosuppressed chickens.
Inventors
- 👤 Karel A. Schat
- 👤 Bruce W. Calnek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:02
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/12; A61K39/245; A61K39/255; C; C12; C12N; C12N7/00; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16311; C12N2710/16321; C12N2710/16334; Y; Y10; Y10S; Y10S424/00; Y10S424/816
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
76 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks with a nononcogenic, unattenuated Marek's disease virus vaccine prepared in accordance with a process which comprises the step of serially passing nononcogenic SB strain of Marek's disease virus or a cloned derivative thereof through cell cultures to increase the virus titer to a useful level but without attenuating the original characteristics of the virus.
Claim 2
Independent Claim
76 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks with a nononcogenic, unattenuated Marek's disease virus vaccine prepared in accordance with a process which comprises the step of serially passing nononcogenic SB strain of Marek's disease virus or a cloned derivative thereof through cell cultures to increase the virus titer to a useful level but without attenuating the original characteristics of the virus.
Claim 3
Independent Claim
115 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising inoculating susceptible chicks with an unattenuated, nononcogenic Marek's disease virus vaccine prepared in accordance with a process which comprises the steps of: a. inoculating a cell culture selected from the group comprising chicken kidney and chicken embryo fibroblast cultures wiht the nononcogenic SB strain of Marek's disease virus or a cloned derivative thereof; b. serially passing the virus to increase virus titer to a useful level, but without attenuating the original characteristics of the virus; c. inoculating chicks with said resulting virus, the resulting virus constituting a vaccine against Marek's disease characterized as an unattenuated, nononcogenic, Marek's disease virus.
Claim 4
Independent Claim
115 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising inoculating susceptible chicks with an unattenuated, nononcogenic Marek's disease virus vaccine prepared in accordance with a process which comprises the steps of: a. inoculating a cell culture selected from the group comprising chicken kidney and chicken embryo fibroblast cultures wiht the nononcogenic SB strain of Marek's disease virus or a cloned derivative thereof; b. serially passing the virus to increase virus titer to a useful level, but without attenuating the original characteristics of the virus; c. inoculating chicks with said resulting virus, the resulting virus constituting a vaccine against Marek's disease characterized as an unattenuated, nononcogenic, Marek's disease virus.
Claim 5
Independent Claim
32 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks, with a nononcogenic, unattenuated Marek's disease virus, known as SB-1.
Claim 6
Independent Claim
32 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks, with a nononcogenic, unattenuated Marek's disease virus, known as SB-1.
Claim 7
Independent Claim
35 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks shortly after hatching, with a nononcogenic, unattenuated Marek's disease virus, known as SB-1.
Claim 8
Independent Claim
35 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks shortly after hatching, with a nononcogenic, unattenuated Marek's disease virus, known as SB-1.
Claim 9
Independent Claim
33 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks with a naturally nononcogenic, unattenuated Marek's disease virus, known as SB.
Claim 10
Independent Claim
33 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks with a naturally nononcogenic, unattenuated Marek's disease virus, known as SB.
Claim 11
Independent Claim
36 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks, shortly after hatching, with a naturally nononcogenic, unattenuated Marek's disease virus, known as SB.
Claim 12
Independent Claim
36 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks, shortly after hatching, with a naturally nononcogenic, unattenuated Marek's disease virus, known as SB.
Claim 13
Independent Claim
40 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks, prior to exposure to oncogenic Marek's disease virus, with a nononcogenic, unattenuated Marek's disease virus, known as SB-1.
Claim 14
Independent Claim
40 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks, prior to exposure to oncogenic Marek's disease virus, with a nononcogenic, unattenuated Marek's disease virus, known as SB-1.
Claim 15
Independent Claim
41 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks, prior to exposure to oncogenic Marek's disease virus, with a naturally nononcogenic, unattenuated Marek's disease virus, known as SB.
Claim 16
Independent Claim
41 words
A method of immunizing chickens against Marek's disease without thereby causing tumors in vaccinated chicks comprising the step of inoculating susceptible chicks, prior to exposure to oncogenic Marek's disease virus, with a naturally nononcogenic, unattenuated Marek's disease virus, known as SB.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-07-02 | 1983-01-01 | 1983-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-07-02 | 1987-01-01 | 1987-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-07-02 | 1991-01-01 | 1991-07-03 | $7700.00 | Window Closed / Lapsed |