Patent US4158626A successfully refreshed from Google Patents.
US4158626A
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Coated carrier materials for thin layer chromatography having a concentrating zone
Assignee: Merck Patent GmbH
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Filing: 1978-05-25
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Granted: 1979-06-19
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Expires: 1998-05-25
Abstract
Abstract TLC plates having a concentrating zone located adjacent to and before a chromatography layer are improved by using as the layer for the concentrating zone a silicon dioxide of medium pore volume (e.g., 0.5-1.5 ml/g) and a pore width of 2-15 μm.
Inventors
- 👤 Herbert Halpaap
- 👤 Karl-Friedrich Krebs
- 👤 Hans Heinz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 20:53
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/02; B01J20/10; B01J20/103; B01J20/28; B01J20/28014; B01J20/2803; B01J20/28054; B01J20/28057; B01J20/28059; B01J20/28069; B01J20/28078; B01J20/28085; B01J20/281; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/3231; B01J20/3234; B01J20/3236; G; G01; G01N; G01N30/00; G01N30/90; G01N30/92; G01N30/93; B01J2220/00; B01J2220/40; B01J2220/49; B01J2220/50; B01J2220/54
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
54 words
In a coated substrate for thin layer chromatography which has a concentrating zone layer located in side by side contact with and before the chromatography layer, the improvement wherein the concentrating zone layer consists essentially of porous silicon dioxide having a pore volume of 0.5 ml/g-1.5 ml/g and a pore width of 2-15 μm.
Claim 2
Dependent Claim
54 words
In a coated substrate for thin layer chromatography which has a concentrating zone layer located in side by side contact with and before the chromatography layer, the improvement wherein the concentrating zone layer consists essentially of porous silicon dioxide having a pore volume of 0.5 ml/g-1.5 ml/g and a pore width of 2-15 μm.
Claim 3
Dependent Claim
25 words
The coated substrate of claim 1, wherein the silicon dioxide of the concentrating zone has a particle size distributed in the range of 10-50 μm.
Claim 4
Dependent Claim
17 words
The coated substrate of claim 1, wherein the layer thickness of the concentrating zone is 100-200 μm.
Claim 5
Dependent Claim
16 words
The coated substrate of claim 3, wherein the layer thickness of the chromatography layer is 200-300μm.
Claim 6
Dependent Claim
26 words
The coated substrate of claim 1, wherein the specific surface area of the silicon dioxide in the concentrating zone is less than 1 m 2 /g.
Claim 7
Dependent Claim
13 words
The coated substrate of claim 1, wherein the pore width is 4-8 μm.
Claim 8
Dependent Claim
17 words
The coated substrate of claim 1, wherein the chromatography layer consists essentially of chromatographically active silica gel.
Claim 9
Dependent Claim
37 words
The coated substrate of claim 1, wherein the layers contain 0.1 to 10 wt.% of binding agents and 0.5 to 5 wt.% of indicator, the wt.% being based on the composition of the layer in finished form.
Claim 10
Dependent Claim
80 words
The coated substrate of claim 1, wherein the silicon dioxide of the concentrating zone is synthetically produced and has a pore volume of 0.5-1.0 ml/g, a pore width of 4-8 μm, a particle size in the range of 10-50 μm and a specific surface area of 0.2-0.8 m 2 /g; the thickness of the concentrating zone layer is 100-200 μm and of the chromatography layer is 200-300 μm; and the chromatography layer consists essentially of a chromatographically active silica gel.
Claim 11
Dependent Claim
48 words
A method of separating components of a test sample which comprises placing the test sample in the concentrating zone of the coated substrate of claim 1 and subsequently placing eluent into the concentrating zone so that the test sample flows from the concentrating zone into the chromatography layer.
References Cited (Backward Citations)
US3303043A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-06-18 | 1982-12-18 | 1983-06-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-06-18 | 1986-12-18 | 1987-06-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-06-18 | 1990-12-18 | 1991-06-19 | $7700.00 | Window Closed / Lapsed |