US4157439A
Expired / Lapsed
US
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Novel nitrosourea derivatives
Assignee: Individual
•
Filing: 1977-08-26
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Granted: 1979-06-05
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Expires: 1997-08-26
Abstract
Abstract Novel nitrosourea derivatives are provided which possess a high inhibitory activity against the leukemia and tumors with a low toxicity and a good stability against humidity and which are useful for pharmaceutical purposes. The compounds have the structure: ##STR1## wherein R 1 represents hydroxyl or alkanoyloxy containing 2-4 carbon atoms; R 2 represents hydrogen or alkanoyl containing 2-4 carbon atoms; R 3 represents alkanoyl containing 2-4 carbon atoms; and R 4 represents alkyl or halo-substituted alkyl containing 1-4 carbon atoms.
Inventors
- 👤 Tetsuo Suami
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 17:15
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/12
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
51 words
Nitrosourea derivative of the formula: ##STR7## wherein R 1 represents a hydroxyl or an alkanoyloxy containing 2-4 carbon atoms; R 2 represents a hydrogen or an alkanoyl containing 2-4 carbon atoms; R 3 represents an alkanoyl containing 2-4 carbon atoms; and R 4 represents a halo-substituted alkyl containing 1-4 carbon atoms.
Claim 2
Dependent Claim
51 words
Nitrosourea derivative of the formula: ##STR7## wherein R 1 represents a hydroxyl or an alkanoyloxy containing 2-4 carbon atoms; R 2 represents a hydrogen or an alkanoyl containing 2-4 carbon atoms; R 3 represents an alkanoyl containing 2-4 carbon atoms; and R 4 represents a halo-substituted alkyl containing 1-4 carbon atoms.
Claim 3
Dependent Claim
15 words
Nitrosourea derivative as claimed in claim 1 wherein R 1 represents a hydroxyl or acetyloxy.
Claim 4
Dependent Claim
15 words
Nitrosourea derivative as claimed in claim 1 wherein R 2 represents a hydrogen or acetyl.
Claim 5
Dependent Claim
13 words
Nitrosourea derivative as claimed in claim 1 wherein R 3 represents an acetyl.
Claim 6
Dependent Claim
18 words
Nitrosourea derivative as claimed in claim 1 wherein R 4 represents a chloro-substituted alkyl containing 1-4 carbon atoms.
Claim 7
Dependent Claim
12 words
Nitrosourea derivative as claimed in claim 5 wherein R 4 represents β-chloroethyl.
Claim 8
Dependent Claim
2 words
1-(2-Chloroethyl)-1-nitroso-3-(2-acetamido-2-deoxy-β-D-glucopyranosyl) urea.
Claim 9
Dependent Claim
2 words
1-(2-Chloroethyl)-1-nitroso-3-(2-acetamido-2-deoxy-β-D-glucopyranosyl) urea.
Claim 10
Dependent Claim
2 words
1-(2-Chloroethyl)-1-nitroso-3-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl) urea.
Claim 11
Dependent Claim
2 words
1-(2-Chloroethyl)-1-nitroso-3-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl) urea.
References Cited (Backward Citations)
US3577406A
Cited
US4022963A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-06-04 | 1982-12-04 | 1983-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-06-04 | 1986-12-04 | 1987-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-06-04 | 1990-12-04 | 1991-06-05 | $7700.00 | Window Closed / Lapsed |