Patent US4157390A successfully refreshed from Google Patents.
US4157390A
Expired / Lapsed
US
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Process for vaccine preparation
Assignee: Internationale Octrooi Maatschappij Octropa BV
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Filing: 1978-07-24
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Granted: 1979-06-05
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Expires: 1998-07-24
Abstract
Abstract A vaccine comprising an antigen selectively adsorbed onto erythrocytes possessing their natural surface characteristics. When the antigen is the K88a,b/adhesion factor of E. coli and the erythrocytes are chicken erythrocytes, the vaccine is especially suitable for reducing the incidence of neonatal diarrhoea in pigs if it is administered parenterally to a sow about three weeks prior to parturition.
Inventors
- 👤 Stephen H. Parry
- 👤 Philip Porter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:11
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/025; A61K39/0258; A61K2039/545; A61K2039/555; A61K2039/55511; A61K2039/55566; A61K2039/60; A61K2039/6006; A61K2039/62; A61K2039/622; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10S; Y10S424/00; Y10S424/825
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
94 words
A process for the preparation of a vaccine for parenteral administraion to pregnant mammals as a means for reducing the incidence of neonatal diarrhoea, in which process K88a,b/adhesion factor of an enteropathogenic strain of E. coli is adsorbed from a cell-free aqueous solution onto erythrocytes possessing their natural surface characteristics, the ratio of adsorbed K88a,b/adhesion factor to the volume of erythrocytes present being in the range 125 to 800 hemagglutination units per ml, and the composition so formed is rendered storable by the addition thereto of a preservative such as sodium azide or formalin.
Claim 2
Dependent Claim
94 words
A process for the preparation of a vaccine for parenteral administraion to pregnant mammals as a means for reducing the incidence of neonatal diarrhoea, in which process K88a,b/adhesion factor of an enteropathogenic strain of E. coli is adsorbed from a cell-free aqueous solution onto erythrocytes possessing their natural surface characteristics, the ratio of adsorbed K88a,b/adhesion factor to the volume of erythrocytes present being in the range 125 to 800 hemagglutination units per ml, and the composition so formed is rendered storable by the addition thereto of a preservative such as sodium azide or formalin.
Claim 3
Dependent Claim
13 words
A process as claimed in claim 1, wherein said erythrocytes are chicken erythrocytes.
Claim 4
Dependent Claim
15 words
An injectable vaccine prepared by a process as claimed in claim 1 or claim 2.
References Cited (Backward Citations)
GB1413799A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-06-04 | 1982-12-04 | 1983-06-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-06-04 | 1986-12-04 | 1987-06-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-06-04 | 1990-12-04 | 1991-06-05 | $7700.00 | Window Closed / Lapsed |