US4156786A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Amino acid derivatives
Assignee: ER Squibb and Sons LLC
•
Filing: 1978-06-26
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Granted: 1979-05-29
•
Expires: 1998-06-26
Abstract
Abstract New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Miguel A. Ondetti
- 👤 Michael E. Condon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 00:43
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/0606; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07C; C07C327/00; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D207/46; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60; C07D211/80; C07D211/84; C07D211/86; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/80
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
83 words
A compound of the formula ##STR14## and salts thereof, wherein R is hydroxy or lower alkoxy R 1 is hydrogen, lower alkanoyl or amino(imino)methyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen, lower alkanoyl, benzoyl or ##STR15## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is hydrogen, lower alkyl, hydroxy-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylthio-lower alkylene, carbamoyl-lower alkylene or carboxy lower alkylene; m is 1, 2, 3 or 4; and n is 0 or 1.
Claim 2
Dependent Claim
83 words
A compound of the formula ##STR14## and salts thereof, wherein R is hydroxy or lower alkoxy R 1 is hydrogen, lower alkanoyl or amino(imino)methyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen, lower alkanoyl, benzoyl or ##STR15## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is hydrogen, lower alkyl, hydroxy-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylthio-lower alkylene, carbamoyl-lower alkylene or carboxy lower alkylene; m is 1, 2, 3 or 4; and n is 0 or 1.
Claim 3
Dependent Claim
27 words
A compound as in claim 1 wherein ##STR16## is the radical of glycine, alanine, leucine, threonine, lysine, arginine, glutamine, methionine, serine, cysteine, valine, asparagine or glutamic acid.
Claim 4
Dependent Claim
56 words
A compound as in claim 1 wherein R is hydroxy; R 1 is hydrogen, lower alkanoyl, or amino(imino)methyl; R 2 is hydrogen or lower alkyl; R 3 is hydrogen, lower alkanoyl or benzoyl; A is hydrogen; B is lower alkyl, guanidino-lower alkylene or amino-lower alkylene; m is 3 or 4 and n is 0 or 1.
Claim 5
Dependent Claim
11 words
A compound as in claim 1 wherein R 3 is ##STR17##
Claim 6
Dependent Claim
10 words
A compound as in claim 1 wherein R is hydroxy.
Claim 7
Dependent Claim
22 words
A compound as in claim 1 wherein R is hydroxy and R 1 , R 2 and R 3 each is hydrogen.
Claim 8
Dependent Claim
33 words
A compound as in claim 1 wherein R is hydroxy, A, R 1 , R 2 and R 3 each is hydrogen, B is lower alkyl, m is 3 and n is 1.
Claim 9
Dependent Claim
32 words
A compound as in claim 1 wherein R is hydroxy, A, R 1 , R 2 and R 3 each is hydrogen, B is guanidinopropyl, m is 3 and n is 1.
Claim 10
Dependent Claim
33 words
A compound as in claim 4 wherein each R is hydroxy, each A, R 1 and R 2 is hydrogen, each m is 3 or 4 and each n is 0 or 1.
Claim 11
Dependent Claim
13 words
A compound as in claim 7 wherein the lower alkyl group is isobutyl.
Claim 12
Dependent Claim
12 words
A compound as in claim 9 wherein each B is lower alkyl.
Claim 13
Dependent Claim
13 words
A compound as in claim 11 wherein the lower alkyl group is isobutyl.
Claim 14
Dependent Claim
32 words
A compound as in claim 1 wherein R is hydroxy; A, R 1 , R 2 and R 3 each is hydrogen, B is 2-(methylthio)ethyl, m is 3 and n is 1.
References Cited (Backward Citations)
US3799918A
Cited
US3959519A
Cited
DE2349707A1
Cited
US3952115A
Cited
US4064235A
Cited
US4024286A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-28 | 1982-11-27 | 1983-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-28 | 1986-11-27 | 1987-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-28 | 1990-11-27 | 1991-05-29 | $7700.00 | Window Closed / Lapsed |