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US4155914A
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Hydroxy-succinimide ester compounds
Assignee: Roche Diagnostics GmbH
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Filing: 1977-07-13
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Granted: 1979-05-22
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Expires: 1997-07-13
Abstract
Abstract New hydroxy-succinimide ester compounds of the formula ##STR1## wherein X is selected from a carboxy-succinimide ester group and radicals of the general formulae: ##STR2## A is --O--CH 2 --CH 2 when n is 2 and X is a succinimide ester group but otherwise is a single bond; N is a whole number of from 2 to 7; M is 1, 2, 3 or 4, R is hydrogen, methyl, or cyanide; and R' is methyl or ethyl; Have been found outstandingly useful as bridge-building compounds for linking proteins, especially biologically active proteins, to solid or liquid carrier matrix materials, thereby yielding valuable carrier-bound enzymatically active protein compositions.
Inventors
- 👤 Hans-Georg Batz
- 👤 Jurgen Horn
- 👤 Klaus Stellner
- 👤 Josef Maier
- 👤 Michael Nelboeck-Hochstetter
- 👤 Gunter Weimann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 10:46
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/46; C08; C08F; C08F20/00; C08F20/02; C08F20/10; C08F20/34; C08F20/36
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
33 words
Hydroxy-succinimide ester compound of the formula ##STR5## wherein X is --CO--NH--CH.sub.2 --CH(OR').sub.2 A is a single bond; n is a whole number of from 2 to 7; and R' is methyl or ethyl.
Claim 2
Dependent Claim
33 words
Hydroxy-succinimide ester compound of the formula ##STR5## wherein X is --CO--NH--CH.sub.2 --CH(OR').sub.2 A is a single bond; n is a whole number of from 2 to 7; and R' is methyl or ethyl.
Claim 3
Dependent Claim
12 words
Hydroxy-succinimide ester compound as claimed in claim 1 wherein R' is methyl.
Claim 4
Dependent Claim
12 words
Hydroxy-succinimide ester compound as claimed in claim 1 wherein R' is ethyl.
Claim 5
Dependent Claim
14 words
Hydroxy-succinimide ester compound as claimed in claim 1 designated oxy-succinimide-glutaric acid aminoacetaldehyde dimethyl acetal.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-21 | 1982-11-20 | 1983-05-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-21 | 1986-11-20 | 1987-05-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-21 | 1990-11-20 | 1991-05-22 | $7700.00 | Window Closed / Lapsed |