Patent US4154834A successfully refreshed from Google Patents.
US4154834A
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Substituted isocytosines having histamine H2 -antagonist activity
Assignee: Smith Kline & French Laboratories Ltd
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Filing: 1977-12-16
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Granted: 1979-05-15
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Expires: 1997-12-16
Abstract
Abstract The compounds are substituted isocytosines which are histamine H2-antagonists. Two specific compounds of the present inventon are 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)- 4-pyrimidone and 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-py rimidone.
Inventors
- 👤 Thomas H. Brown
- 👤 Graham J. Durant
- 👤 Charon R. Ganellin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:50
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/14; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/56; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 53
Claim 1
Independent Claim
279 words
A compound of the formula: ##STR12## wherein Het is 2- or 4-imidazolyl optionally monosubstituted by lower alkyl, halogen, trifluoromethyl or hydroxymethyl; 2-pyridyl optionally substituted by one or two groups (which may be the same or different) selected from lower alkyl, lower alkoxy, halogen, amino and hydroxy; 2-pyridyl with a phenyl, carbocyclic or cyclic ether ring having 2 oxygen atoms fused to it; 2-thiazolyl; 3-isothiazolyl optionally monosubstituted by chlorine or bromine; 3-(1,2,5)-thiadiazolyl optionally monosubstituted by chlorine or bromine, or 2-(5-amino-1,3,4-thiadiazolyl); Y is sulphur or a methylene group; m is 0, 1 or 2 and n is 2 or 3 such that their sum is 3 or 4 or when Y is methylene and Het is other than an imidazole ring, 2; Z is hydrogen or lower alkyl; X is oxygen or sulphur; A is a straight or branched alkylene chain having from 1-5 carbon atoms or --(CH 2 ) p W(CH 2 ) q -- where W is oxygen or sulphur and p and q are such that their sum is from 1 to 4; Het' is a 5 or 6 membered heterocyclic ring selected from pyridine, pyridine-N-oxide, furan, thiophen, thiazole, oxazole, isothiazole, imidazole, pyrimidine, pyrazine, pyridazine or thiadiazole, which ring is optionally substituted by one or two (which may be the same or different) of the groups selected from lower alkyl, lower alkoxy, halo, hydroxy and amino, or Het' is a pyridine ring with a carbocyclic or cyclic ether ring having two oxygen atoms fused to it, or Het' is a pyridine, imidazole or thiazole ring which has a benzene ring fused to it, said Het' being attached at a ring carbon atom; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
279 words
A compound of the formula: ##STR12## wherein Het is 2- or 4-imidazolyl optionally monosubstituted by lower alkyl, halogen, trifluoromethyl or hydroxymethyl; 2-pyridyl optionally substituted by one or two groups (which may be the same or different) selected from lower alkyl, lower alkoxy, halogen, amino and hydroxy; 2-pyridyl with a phenyl, carbocyclic or cyclic ether ring having 2 oxygen atoms fused to it; 2-thiazolyl; 3-isothiazolyl optionally monosubstituted by chlorine or bromine; 3-(1,2,5)-thiadiazolyl optionally monosubstituted by chlorine or bromine, or 2-(5-amino-1,3,4-thiadiazolyl); Y is sulphur or a methylene group; m is 0, 1 or 2 and n is 2 or 3 such that their sum is 3 or 4 or when Y is methylene and Het is other than an imidazole ring, 2; Z is hydrogen or lower alkyl; X is oxygen or sulphur; A is a straight or branched alkylene chain having from 1-5 carbon atoms or --(CH 2 ) p W(CH 2 ) q -- where W is oxygen or sulphur and p and q are such that their sum is from 1 to 4; Het' is a 5 or 6 membered heterocyclic ring selected from pyridine, pyridine-N-oxide, furan, thiophen, thiazole, oxazole, isothiazole, imidazole, pyrimidine, pyrazine, pyridazine or thiadiazole, which ring is optionally substituted by one or two (which may be the same or different) of the groups selected from lower alkyl, lower alkoxy, halo, hydroxy and amino, or Het' is a pyridine ring with a carbocyclic or cyclic ether ring having two oxygen atoms fused to it, or Het' is a pyridine, imidazole or thiazole ring which has a benzene ring fused to it, said Het' being attached at a ring carbon atom; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
164 words
A compound of claim 1 wherein Het is 2-or 4-imidazolyl optionally monosubstituted by lower alkyl, halogen, trifluoromethyl or hydroxymethyl; 2-pyridyl optionally monosubstituted by lower alkyl, lower alkoxy, halogen, amino or hydroxy; 2-thiazolyl; 3-isothiazolyl optionally monosubstituted by chlorine or bromine; 3-(1,2,5)-thiadiazolyl optionally monosubstituted by chlorine or bromine, or 2-(5-amino-1,3,4-thiadiazolyl); m is 1 and n is 2; A is a straight alkylene chain having from 1-5 carbon atoms or --(CH 2 ) p W(CH 2 ) q -- where w is oxygen or sulphur and p and q are such that their sum is from 1 to 4; and Het' is a 5 or 6 membered heterocyclic ring selected from pyridine, furan, thiophen, thiazole, oxazole, isothiazole, imidazole, pyrimidine, pyrazine or pyridazine, which ring is optionally monosubstituted by lower alkyl or lower alkoxy, or Het' is a pyridine, imidazole or thiazole which ring has a benzene ring fused to it, said Het' being attached at a ring carbon atom; or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
18 words
A compound of claim 1 wherein Het is 2-thiazolyl, 5-methyl-4-imidazolyl, 5-bromo-4-imidazolyl, 3-bromo-2-pyridyl, 3-chloro-2-pyridyl, 3-methoxy-2-pyridyl, 3-hydroxy-2-pyridyl, 4-methyl-3-bromo-2-pyridyl or 4-methyl-3-chloro-2pyridyl.
Claim 5
Dependent Claim
9 words
A compound of claim 1 wherein Y is sulphur.
Claim 6
Dependent Claim
9 words
A compound of claim 1 wherein X is oxygen.
Claim 7
Dependent Claim
9 words
A compound of claim 1 wherein Z is hydrogen.
Claim 8
Dependent Claim
12 words
A compound of claim 1 wherein A is a straight alkylene chain.
Claim 9
Dependent Claim
9 words
A compound of claim 1 wherein A is methylene.
Claim 10
Dependent Claim
46 words
A compound of claim 1 wherein Het' is 2-furyl, 2-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thiazolyl, 2-imidazolyl, 2-pyrimidyl, 2-pyrazyl or 3-pyridazyl, which ring is optionally monosubstituted by lower alkyl or lower alkoxy, and optionally when Het' is pyridyl, thiazolyl or imidazolyl has a benzene ring fused to it.
Claim 11
Dependent Claim
14 words
A compound of claim 1 wherein Het' is 2-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl or 2-thiazolyl.
Claim 12
Dependent Claim
9 words
A compound of claim 1 wherein Het' is 3-pyridyl.
Claim 13
Dependent Claim
17 words
A compound of claim 1 wherein Het' is pyridine, pyridine N-oxide, furan, thiophen, pyrazine, pyridazine or thiadiazole.
Claim 14
Dependent Claim
32 words
A compound of claim 1 wherein Het' is pyridine, pyridine N-oxide, furan, thiophen, pyrazine, pyridazine or thiadiazole, which ring is substituted by a lower alkyl, lower alkoxy, halo, hydroxy or amino group.
Claim 15
Dependent Claim
24 words
A compound of claim 1 wherein Het' is a pyridine ring with two substituents selected from lower alkyl, lower alkoxy, halo, hydroxy and amino.
Claim 16
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone.
Claim 17
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(2-thiazolylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone.
Claim 18
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(4-pyridylmethyl)-4-pyrimidone.
Claim 19
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-thienylmethyl)-4-pyrimidone.
Claim 20
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-pyridylmethyl)-4-pyrimidone.
Claim 21
Dependent Claim
9 words
A compund of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 22
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(2-pyridylmethyl)-4-pyrimidone.
Claim 23
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-thiazolylmethyl)-4-pyrimidone.
Claim 24
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(2-thiazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 25
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 26
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-fluoro-2-pyridylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 27
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-iodo-2-pyridylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 28
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[4-(4-imidazolyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 29
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 30
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)-6-methyl-4-pyrimidone.
Claim 31
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-bromo-4-methyl-2-pyridylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 32
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-quinolylmethyl)-4-pyrimidone.
Claim 33
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(2-thiazolylmethylthio)ethylamino]-5-(3-quinolylmethyl)-4-pyrimidone.
Claim 34
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-methoxy-2-pyridylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 35
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-chloro-2-pyridylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 36
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[4-(3-bromo-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 37
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[3-(5-methyl-4-imidazolylmethylthio)propylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 38
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
Claim 39
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(2-thiazolylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
Claim 40
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
Claim 41
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[4-(5-methyl-4-imidazolyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
Claim 42
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
Claim 43
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(1-(3-pyridyl)ethyl)-4-pyrimidone.
Claim 44
Dependent Claim
9 words
A compound of claim 1, said compound being 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)-6-methyl-4-pyrimidone.
Claim 45
Dependent Claim
24 words
A pharmaceutical compositon to block histamine H 2 -receptors comprising a compound of claim 1 in combination with a pharmaceutically acceptable diluent or carrier.
Claim 46
Dependent Claim
22 words
A method of blocking histamine H 2 -receptors which comprises administering to an animal in need thereof a compound of claim 1.
Claim 47
Dependent Claim
28 words
A method of simultaneously blocking histamine H 1 -receptors and histamine H 2 -receptors which comprises administering to an animal in need thereof a compound of claim 1.
Claim 48
Dependent Claim
18 words
A pharmaceutical composition according to claim 44 comprising 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone in combination with a pharmaceutically acceptable diluent or carrier.
Claim 49
Dependent Claim
18 words
A pharmaceutical composition according to claim 44 comprising 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone in combination with a pharmaceutically acceptable diluent or carrier.
Claim 50
Dependent Claim
25 words
A method of simultaneously blocking histamine H 1 -receptors and histamine H 2 -receptors according to claim 46 which comprises administering to an animal 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
Claim 51
Dependent Claim
25 words
A method of simultaneously blocking histamine H 1 -receptors and histamine H 2 -receptors according to claim 46 which comprises administering to an animal 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(3-pyridylmethyl)-4-pyrimidone.
Claim 52
Dependent Claim
10 words
A compound of claim 1, said compound being 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone trihydrochloride.
Claim 53
Dependent Claim
19 words
A pharmaceutical composition according to claim 44 comprising 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone trihydrochloride in combination with a pharmaceutically acceptable diluent or carrier.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-14 | 1982-11-13 | 1983-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-14 | 1986-11-13 | 1987-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-14 | 1990-11-13 | 1991-05-15 | $7700.00 | Window Closed / Lapsed |