Abstract The invention is directed to pharmaceutical and veterinary preparations having antibacterial action characterized by the contents of the following two bactericidally active substances (1) a rifamycin compound (2) a nitrofuran compound They show a synergistic enhancement of the bactericidal action as compared with the single antibactericidal components when given alone and they also suppress or prevent the development of resistance towards these antibiotics or antibacterial agents, especially towards rifampicin. Preferred ratios of the quantities of (1) and (2) contained in these preparations are 6:1 and 2:1. An especially suitable combination is rifampicin and nitrofurantoin. Other examples are the combination of 3-amino-rifamycin SV derivaties with known nitrofuran derivatives, such as nitrofurantoin, furzolidone or furaltadone.
A method for treating bacterial infections in humans and animals which comprises administering to said human or animal an antibacterially effective amount of a preparation of (1) rifampicin and (2) nitrofurantoin wherein the two components (1) and (2) are present in a ratio of from 6:1 to 1:1.
Claim 2
Independent Claim
48 words
A method for treating bacterial infections in humans and animals which comprises administering to said human or animal an antibacterially effective amount of a preparation of (1) rifampicin and (2) nitrofurantoin wherein the two components (1) and (2) are present in a ratio of from 6:1 to 1:1.
Claim 3
Dependent Claim
11 words
A method of claim 1, wherein the preparation is orally administered.
Claim 4
Dependent Claim
11 words
A method of claim 1, wherein the preparation is parenterally administered.
Claim 5
Dependent Claim
16 words
A method of claim 1, wherein the preparation is administered in the form of gelatine capsules.
Claim 6
Dependent Claim
32 words
A pharmaceutical and veterinary preparation for treating bacterial infections comprising (1) refampicin and (2) nitrofurantoin wherein the two components (1) and (2) are present in a ratio of from 6:1 to 1:1.
Claim 7
Dependent Claim
32 words
A pharmaceutical and veterinary preparation for treating bacterial infections comprising (1) refampicin and (2) nitrofurantoin wherein the two components (1) and (2) are present in a ratio of from 6:1 to 1:1.
Claim 8
Dependent Claim
18 words
The preparation of claim 5, which contains the two components (1) and (2) in a ratio of 6:1.
Claim 9
Dependent Claim
18 words
The preparation of claim 5, which contains the two components (1) and (2) in a ratio of 2:1.
Claim 10
Dependent Claim
15 words
The preparation of claim 5, which contains 50 mg of rifampicin in the dosage unit.
Claim 11
Dependent Claim
20 words
The preparation of claim 5, which contains 150 mg of nitrofurantoin and 300 mg of rifampicin in the dosage unit.