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US4152444A Expired / Lapsed US ⏱️ 0.0 years remaining

Pharmaceutical compound preparations with bactericidal action

Assignee: Novartis Corp
•
Filing: 1977-08-29
•
Granted: 1979-05-01
•
Expires: 1997-08-29
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Abstract

Abstract The invention is directed to pharmaceutical and veterinary preparations having antibacterial action characterized by the contents of the following two bactericidally active substances (1) a rifamycin compound (2) a nitrofuran compound They show a synergistic enhancement of the bactericidal action as compared with the single antibactericidal components when given alone and they also suppress or prevent the development of resistance towards these antibiotics or antibacterial agents, especially towards rifampicin. Preferred ratios of the quantities of (1) and (2) contained in these preparations are 6:1 and 2:1. An especially suitable combination is rifampicin and nitrofurantoin. Other examples are the combination of 3-amino-rifamycin SV derivaties with known nitrofuran derivatives, such as nitrofurantoin, furzolidone or furaltadone.

Inventors

  • 👤 Wolfgang Vischer
  • 👤 Friedrich Kradolfer

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-24 17:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 48 words
A method for treating bacterial infections in humans and animals which comprises administering to said human or animal an antibacterially effective amount of a preparation of (1) rifampicin and (2) nitrofurantoin wherein the two components (1) and (2) are present in a ratio of from 6:1 to 1:1.
Claim 2
Independent Claim 48 words
A method for treating bacterial infections in humans and animals which comprises administering to said human or animal an antibacterially effective amount of a preparation of (1) rifampicin and (2) nitrofurantoin wherein the two components (1) and (2) are present in a ratio of from 6:1 to 1:1.
Claim 3
Dependent Claim 11 words
A method of claim 1, wherein the preparation is orally administered.
Claim 4
Dependent Claim 11 words
A method of claim 1, wherein the preparation is parenterally administered.
Claim 5
Dependent Claim 16 words
A method of claim 1, wherein the preparation is administered in the form of gelatine capsules.
Claim 6
Dependent Claim 32 words
A pharmaceutical and veterinary preparation for treating bacterial infections comprising (1) refampicin and (2) nitrofurantoin wherein the two components (1) and (2) are present in a ratio of from 6:1 to 1:1.
Claim 7
Dependent Claim 32 words
A pharmaceutical and veterinary preparation for treating bacterial infections comprising (1) refampicin and (2) nitrofurantoin wherein the two components (1) and (2) are present in a ratio of from 6:1 to 1:1.
Claim 8
Dependent Claim 18 words
The preparation of claim 5, which contains the two components (1) and (2) in a ratio of 6:1.
Claim 9
Dependent Claim 18 words
The preparation of claim 5, which contains the two components (1) and (2) in a ratio of 2:1.
Claim 10
Dependent Claim 15 words
The preparation of claim 5, which contains 50 mg of rifampicin in the dosage unit.
Claim 11
Dependent Claim 20 words
The preparation of claim 5, which contains 150 mg of nitrofurantoin and 300 mg of rifampicin in the dosage unit.

References Cited (Backward Citations)

US3751567A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1982-04-30 1982-10-30 1983-05-01 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1986-04-30 1986-10-30 1987-05-01 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1990-04-30 1990-10-30 1991-05-01 $7700.00 Window Closed / Lapsed

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