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US4150744A Expired / Lapsed US ⏱️ 0.0 years remaining

Packaging

Assignee: Chauvin Pharmaceuticals Ltd
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Filing: 1977-11-23
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Granted: 1979-04-24
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Expires: 1997-11-23
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Abstract

Abstract A light-sensitive and oxygen-sensitive liquid such as an adrenalin solution for ophthalmic use is sealed within a polymer vessel provided with a dropper spout, the closed vessel itself being sealed within a light-tight gas-impermeable envelope which is purged with a non-reactive gas or is under vacuum. The envelope is preferably a three-component laminate of nylon aluminum foil and polypropylene.

Inventors

  • 👤 Jack Fennimore

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-25 06:39
CPC Classifications
B; B65; B65D; B65D75/00; B65D75/26; A; A61; A61J; A61J1/00; A61J1/14; A61J1/16; A61M; A61M11/00; A61M11/006; A61M11/008; A61F; A61F9/00; A61F9/0008; A61M15/00; A61M15/08; A61M2209/00; A61M2209/06; A61M2210/00; A61M2210/06; A61M2210/0612

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 296 words
A packaged medicant comprising (1) an outer hermetically sealed envelope, (2) an inner dispenser bottle, and (3) an inert atmosphere within the envelope within which the dispenser bottle is immersed; said hermetically sealed envelope comprising a three-ply laminate wherein the outer ply is an abrasive-resistant polymer, an intermediate ply which is aluminum foil, and an inner ply which is a heat-sealable polymer, said three-ply laminate in combination excluding entry of oxygen and light and preventing escape of water vapor and the inert atmosphere; said inert atmosphere within the envelope being oxygen; free; and said dispensing bottle being a translucent polymer and containing a solution of light-sensitive, oxygensensitive medicant and an anti-oxident and comprising a receptacle for holding a predetermined quantity of the liquid medicant provided with a neck defining an opening to the interior of the receptacle, a discharge element comprising a cylindrical part press-fitted into the opening in the neck, a tapered nozzle through which the liquid medicant in the receptacle is adapted to be dispensed in predetermined doses, and an annular, externally-located collar in conjunction with the cylindrical part and the tapered nozzle for seating of the discharge element within the neck, said tapered nozzle terminating in an end opening of a diameter to dispense said predetermined dose and said receptacle having elastically flexible walls such as to enable squeezing the walls to displace a dose through the opening at the end of said tapered nozzle, a closure cap arranged to be releasably applied to the neck over the tapered nozzle and a sealing element interiorly of the cap arranged to become engaged with the opening at the end of the nozzle when the cap is applied to the neck to provide a leaktight barrier between the opening and the interior of the cap.
Claim 2
Dependent Claim 296 words
A packaged medicant comprising (1) an outer hermetically sealed envelope, (2) an inner dispenser bottle, and (3) an inert atmosphere within the envelope within which the dispenser bottle is immersed; said hermetically sealed envelope comprising a three-ply laminate wherein the outer ply is an abrasive-resistant polymer, an intermediate ply which is aluminum foil, and an inner ply which is a heat-sealable polymer, said three-ply laminate in combination excluding entry of oxygen and light and preventing escape of water vapor and the inert atmosphere; said inert atmosphere within the envelope being oxygen; free; and said dispensing bottle being a translucent polymer and containing a solution of light-sensitive, oxygensensitive medicant and an anti-oxident and comprising a receptacle for holding a predetermined quantity of the liquid medicant provided with a neck defining an opening to the interior of the receptacle, a discharge element comprising a cylindrical part press-fitted into the opening in the neck, a tapered nozzle through which the liquid medicant in the receptacle is adapted to be dispensed in predetermined doses, and an annular, externally-located collar in conjunction with the cylindrical part and the tapered nozzle for seating of the discharge element within the neck, said tapered nozzle terminating in an end opening of a diameter to dispense said predetermined dose and said receptacle having elastically flexible walls such as to enable squeezing the walls to displace a dose through the opening at the end of said tapered nozzle, a closure cap arranged to be releasably applied to the neck over the tapered nozzle and a sealing element interiorly of the cap arranged to become engaged with the opening at the end of the nozzle when the cap is applied to the neck to provide a leaktight barrier between the opening and the interior of the cap.
Claim 3
Dependent Claim 28 words
A package according to claim 1 containing a tear notch at one of its marginal edges to enable rupturing the envelope to afford access to the dispenser bottle.
Claim 4
Dependent Claim 198 words
A packaged medicant comprising a hermetically sealed envelope filled with an inert atmostphere and containing with the inert atmosphere a squeeze bottle dispenser containing a liquid solution of light-sensitive, oxygen-sensitive medicant and an anti-oxident; said envelope being comprised of a laminate of three plies, an outer ply of nylon which is abrasive-resistant, an intermediate ply of aluminum foil which is opaque and an inner ply of a heat-sealable polymer, said laminate excluding entry of oxygen and light into the envelope and preventing escape of the inert atmosphere and moisture from the envelope, said inert atmosphere within the envelope being oxygen-free and said squeeze bottle dispenser comprising a translucent body portion for holding a quantity of the solution and a nozzle part containing an end opening for dispensing the liquid medicant from the body part in predetermined doses, said body part having elastically-displaceable wall portions which may be squeezed to cause the liquid medicant to be dispensed in predetermined doses through the nozzle part and a cap applied to the body part over the nozzle part which, by engagement with the open end of the nozzle part, provides a barrier to the atmosphere within the cap around the nozzle.
Claim 5
Dependent Claim 198 words
A packaged medicant comprising a hermetically sealed envelope filled with an inert atmostphere and containing with the inert atmosphere a squeeze bottle dispenser containing a liquid solution of light-sensitive, oxygen-sensitive medicant and an anti-oxident; said envelope being comprised of a laminate of three plies, an outer ply of nylon which is abrasive-resistant, an intermediate ply of aluminum foil which is opaque and an inner ply of a heat-sealable polymer, said laminate excluding entry of oxygen and light into the envelope and preventing escape of the inert atmosphere and moisture from the envelope, said inert atmosphere within the envelope being oxygen-free and said squeeze bottle dispenser comprising a translucent body portion for holding a quantity of the solution and a nozzle part containing an end opening for dispensing the liquid medicant from the body part in predetermined doses, said body part having elastically-displaceable wall portions which may be squeezed to cause the liquid medicant to be dispensed in predetermined doses through the nozzle part and a cap applied to the body part over the nozzle part which, by engagement with the open end of the nozzle part, provides a barrier to the atmosphere within the cap around the nozzle.
Claim 6
Dependent Claim 31 words
A package according to claim 3 wherein the outer layer is 10-70 g/m 2 , the intermediate layer is 5-50 g/m 2 and the inner layer is 5-25 g/m 2 .
Claim 7
Dependent Claim 33 words
A package according to claim 3 wherein the liquid solution is adrenaline and N-acetyl-cysteine and wherein the oxidative loss is such that after two years storage at least 50% of the N-acetyl-cysteine remains.

References Cited (Backward Citations)

US2849739A Cited
US2731053A Cited
US3032182A Cited
US3347419A Cited
US3616190A Cited
US3958721A Cited
US4051265A Cited
US4022206A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1982-04-23 1982-10-23 1983-04-24 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1986-04-23 1986-10-23 1987-04-24 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1990-04-23 1990-10-23 1991-04-24 $7700.00 Window Closed / Lapsed

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