Patent US4148883A successfully refreshed from Google Patents.
US4148883A
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Antibiotics produced by new species of nocardia
Assignee: Pfizer Inc
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Filing: 1977-08-18
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Granted: 1979-04-10
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Expires: 1997-08-18
Abstract
Abstract {PG,1 A new species of Nocardia, designated {i Nocardia argentinensis {l Huang sp. nov., when subjected to aerobic submerged fermentation, produces a mixture of new antibiotics. Methods for the recovery and purification of these antibiotics are described and some of their antimicrobial properties are outlined.
Inventors
- 👤 Walter D. Celmer
- 👤 Walter P. Cullen
- 👤 Charles E. Moppett
- 👤 Mark T. Jefferson
- 👤 Liang H. Huang
- 👤 Riichiro Shibakawa
- 👤 Junsuki Tone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:15
CPC Classifications
C; C07; C07G; C07G11/00; A; A61; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
42 words
An antibiotic mixture produced by cultivating Nocardia argentinensis Huang sp. nov. ATCC 31306 under submerged aerobic conditions in an aqueous nutrient medium containing an assimilable source of carbon and nitrogen until substantial antibiotic activity is obtained and separating said antibiotic mixture therefrom.
Claim 2
Dependent Claim
42 words
An antibiotic mixture produced by cultivating Nocardia argentinensis Huang sp. nov. ATCC 31306 under submerged aerobic conditions in an aqueous nutrient medium containing an assimilable source of carbon and nitrogen until substantial antibiotic activity is obtained and separating said antibiotic mixture therefrom.
Claim 3
Dependent Claim
105 words
Antibiotic Compound 47,444 which is soluble in methanol, ethanol, chloroform, methylene chloride, acetone, methylisobutyl ketone and ethyl acetate; insoluble in heptane and water; has absorption maximum in methanol in the ultraviolet light region of the spectrum at 265 nm with E 1cm 1% value of 320; has the molecular formula of C 28 H 37 NO 8 ; has an optical rotation of [α] D =+49° at a concentration of 1% in methanol; and when pelleted in KBr, exhibits characteristic absorption in the infrared region of the following wavelengths in microns: 2.90, 3.40, 5.76, 5.87, 6.40, 6.85, 7.05, 7.63, 8.53, 9.0, 10.58, 11.34 and 13.35.
Claim 4
Dependent Claim
105 words
Antibiotic Compound 47,444 which is soluble in methanol, ethanol, chloroform, methylene chloride, acetone, methylisobutyl ketone and ethyl acetate; insoluble in heptane and water; has absorption maximum in methanol in the ultraviolet light region of the spectrum at 265 nm with E 1cm 1% value of 320; has the molecular formula of C 28 H 37 NO 8 ; has an optical rotation of [α] D =+49° at a concentration of 1% in methanol; and when pelleted in KBr, exhibits characteristic absorption in the infrared region of the following wavelengths in microns: 2.90, 3.40, 5.76, 5.87, 6.40, 6.85, 7.05, 7.63, 8.53, 9.0, 10.58, 11.34 and 13.35.
Claim 5
Dependent Claim
27 words
A pharmaceutical composition suitable for combating Staphylococcal infections in animals comprising a pharmaceutically-acceptable carrier and a therapeutically-effective antistaphylococcal amount of Compound 47,444 as defined in claim 2.
References Cited (Backward Citations)
US4038383A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-09 | 1982-10-09 | 1983-04-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-09 | 1986-10-09 | 1987-04-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-09 | 1990-10-09 | 1991-04-10 | $7700.00 | Window Closed / Lapsed |