Abstract A process and apparatus are provided for making hollow macrospherical particles. The particles themselves are particularly adapted for use as anti-perspirants. The particles have a diameter between about 10 and 74 microns, preferably predominating between 15 and 44 microns, and a greater than unit density. As such, they are not subject to deep lung penetration. The process for producing the particles comprises providing a solution containing the materials from which the particles are made, diffusing the solution through small pores by centrifugal force such that the resulting hollow particles have a diameter greater than the pore diameter, and drying the solution droplets in a stream of heated air. The apparatus for producing the macrospherical particles comprises a centrifugal atomizer having a porous sintered metal filter ring which is rotated inside a spray drying chamber. The filter is treated to produce hollow macrospheres having substantially smooth outer walls of such thickness that they can withstand normal shipment and handling without significant fragmentation.
Hollow, thick-walled macrospherical particles, said walls consisting essentially of anti-perspirant material, at least about 85 percent of said particles having diameters greater than 15 microns and few of said particles having diameters greater than 74 microns, said particles having a true density greater than 1, the walls of said particles having sufficient thickness to withstand shipping, handling and dispensing without substantial fragmentation into smaller particles which may be respired and retained in the lungs.
Claim 2
Dependent Claim
74 words
Hollow, thick-walled macrospherical particles, said walls consisting essentially of anti-perspirant material, at least about 85 percent of said particles having diameters greater than 15 microns and few of said particles having diameters greater than 74 microns, said particles having a true density greater than 1, the walls of said particles having sufficient thickness to withstand shipping, handling and dispensing without substantial fragmentation into smaller particles which may be respired and retained in the lungs.
Claim 3
Dependent Claim
61 words
Macrospherical particles according to claim 1 wherein said anti-perspirant material includes basic aluminum compounds having the formula: Al.sub.n (OH).sub.x A.sub.y.X H.sub.2 O, wherein x and y need not be integers but x+y=3n, X is a quantity from 2 to 4 which need not be an integer, and A is selected from the group consisting of chlorine, bromine, iodine and mixtures thereof.
Claim 4
Dependent Claim
32 words
Macrospherical particles according to claim 1 wherein said anti-perspirant material comprises basic aluminum compounds selected from the group consisting of basic aluminum-zirconium complexes, basic aluminum-magnesium complexes, basic aluminum-polyol complexes and mixtures thereof.
Claim 5
Dependent Claim
12 words
Macrospherical particles according to claim 1 wherein said particles are magnesium-zirconium complexes.
Claim 6
Dependent Claim
14 words
Macrospherical particles according to claim 1 wherein said particles have substantially smooth exterior surfaces.
Claim 7
Dependent Claim
16 words
Macrospherical particles according to claim 1 wherein said particles have an average diameter of 30 microns.