Patent US4146643A successfully refreshed from Google Patents.
US4146643A
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Increasing vigilance or treating cerebral insufficiency with substituted vincamines
Assignee: Sandoz AG
•
Filing: 1977-12-02
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Granted: 1979-03-27
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Expires: 1997-12-02
Abstract
Abstract Halo-, hydroxy-, alkyl- and alkoxy-vincamine derivatives are useful vigilance increasing agents.
Inventors
- 👤 Paul Pfaffli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:32
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/14; C07D209/16; C07D461/00
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
33 words
A compound of formula I, ##STR13## wherein R 1 is bromine, fluorine, chlorine, or lower alkyl, or a pharmaceutically acceptable acid addition salt thereof, in racemic form or in individual optical isomer form.
Claim 2
Dependent Claim
33 words
A compound of formula I, ##STR13## wherein R 1 is bromine, fluorine, chlorine, or lower alkyl, or a pharmaceutically acceptable acid addition salt thereof, in racemic form or in individual optical isomer form.
Claim 3
Dependent Claim
8 words
The compound of claim 1 which is 10-fluorovincamine.
Claim 4
Dependent Claim
8 words
The compound of claim 1, which is 11-bromovincamine.
Claim 5
Dependent Claim
8 words
The compound of claim 1, which is 9-fluorovincamine.
Claim 6
Dependent Claim
8 words
The compound of claim 1, which is 11-chlorovincamine.
Claim 7
Dependent Claim
8 words
The compound of claim 1, which is 12-methylvincamine.
Claim 8
Dependent Claim
8 words
A compound of claim 1 in racemic form.
Claim 9
Dependent Claim
10 words
A compound of claim 1 in individual optical isomer form.
Claim 10
Dependent Claim
9 words
A compound of claim 8 having the (3S,14S,16S) configuration.
Claim 11
Dependent Claim
9 words
A compound of claim 8 having the (3R,14R,16R) configuration.
Claim 12
Dependent Claim
8 words
A 14-epi-isomer of a compound of claim 1.
Claim 13
Dependent Claim
10 words
A compound of claim 1, wherein R 1 is bromine.
Claim 14
Dependent Claim
10 words
A compound of claim 1, wherein R 1 is fluorine.
Claim 15
Dependent Claim
10 words
A compound of claim 1, wherein R 1 is chlorine.
Claim 16
Dependent Claim
11 words
A compound of claim 1, wherein R 1 is lower alkyl.
Claim 17
Dependent Claim
12 words
A compound of claim 1, wherein R 1 is in the 9-position.
Claim 18
Dependent Claim
12 words
A compound of claim 1, wherein R 1 is in the 10-position.
Claim 19
Dependent Claim
12 words
A compound of claim 1, wherein R 1 is in the 11-position.
Claim 20
Dependent Claim
12 words
A compound of claim 1, wherein R 1 is in the 12-position.
Claim 21
Dependent Claim
13 words
A compound of claim 1, wherein R 1 is Br in the 10-position.
Claim 22
Dependent Claim
11 words
A compound of claim 1, chosen from (3S,14S,16S)-10-fluorovincamine, (3S,14S,16S)-10-bromovincamine, and (3S,14S,16S)-11-bromovincamine.
Claim 23
Dependent Claim
25 words
A vigilance increasing pharmaceutical composition comprising an effective vigilance increasing amount of a compound of claim 1 in association with a pharmaceutical carrier or diluent.
Claim 24
Dependent Claim
28 words
A method of increasing vigilance in animals, which comprises administering to an animal in need of such treatment a therapeutically effective amount of a compound of claim 1.
Claim 25
Dependent Claim
29 words
A method of treating cerebral insufficiency in animals, which comprises administering to an animal in need of such treatment a therapeutically effective amount of a compound of claim 1.
References Cited (Backward Citations)
US3755335A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-26 | 1982-09-25 | 1983-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-26 | 1986-09-25 | 1987-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-26 | 1990-09-25 | 1991-03-27 | $7700.00 | Window Closed / Lapsed |