US4146640A
Expired / Lapsed
US
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Complement inhibitors
Assignee: Wyeth Holdings LLC
•
Filing: 1978-02-06
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Granted: 1979-03-27
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Expires: 1998-02-06
Abstract
Abstract Certain C-substituted trisulfonic acids, acid ureides, oxalyl amides and salts thereof useful as complement inhibitors.
Inventors
- 👤 Robert H. Lenhard
- 👤 Seymour Bernstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:44
CPC Classifications
C; C07; C07C; C07C303/00; C07C303/32; A; A61; A61K; A61K31/00; A61K31/185; Y; Y10; Y10S; Y10S436/00; Y10S436/821
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
58 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR13## wherein R is ##STR14## and A is hydrogen, alkali metal or alkaline earth, with the proviso that each A is identical in the same compound.
Claim 2
Independent Claim
58 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR13## wherein R is ##STR14## and A is hydrogen, alkali metal or alkaline earth, with the proviso that each A is identical in the same compound.
Claim 3
Independent Claim
37 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR15## wherein R is ##STR16##
Claim 4
Independent Claim
37 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR15## wherein R is ##STR16##
Claim 5
Dependent Claim
14 words
A method according to claim 2 wherein the compound is 8,8'-{oxalylbis{{[imino(4-methyl-1,3-phenylene)]carbonyl}imino}}di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 6
Independent Claim
57 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a pharmaceutically acceptable compound of the formula ##STR17## wherein R is ##STR18## and A is hydrogen, alkali metal or alkaline earth, with the proviso that each A is identical in the same compound.
Claim 7
Independent Claim
57 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a pharmaceutically acceptable compound of the formula ##STR17## wherein R is ##STR18## and A is hydrogen, alkali metal or alkaline earth, with the proviso that each A is identical in the same compound.
Claim 8
Independent Claim
36 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a pharmaceutically acceptable compound of the formulae ##STR19## wherein R is ##STR20##
Claim 9
Independent Claim
36 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a pharmaceutically acceptable compound of the formulae ##STR19## wherein R is ##STR20##
Claim 10
Dependent Claim
14 words
A method according to claim 5 wherein the compound is 8,8'-{oxalylbis{{[imino(4-methyl-1,3-phenylene)]carbonyl}imino}}di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 11
Dependent Claim
12 words
A method according to claim 5 wherein the compound is administered intra-articularly.
References Cited (Backward Citations)
US3897434A
Cited
US3903106A
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US4027038A
Cited
US4046805A
Cited
US4051176A
Cited
US4087548A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-26 | 1982-09-25 | 1983-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-26 | 1986-09-25 | 1987-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-26 | 1990-09-25 | 1991-03-27 | $7700.00 | Window Closed / Lapsed |