US4087548A
Expired / Lapsed
US
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Complement inhibitors
Assignee: Wyeth Holdings LLC
•
Filing: 1976-05-10
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Granted: 1978-05-02
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Expires: 1996-05-10
Abstract
Abstract C-substituted trisulfonic acids, acid ureides, oxalyl amides and salts thereof useful as complement inhibitors.
Inventors
- 👤 Robert Herman Lenhard
- 👤 Seymour Bernstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 10:11
CPC Classifications
C; C07; C07C; C07C303/00; C07C303/32; A; A61; A61K; A61K31/00; A61K31/185; Y; Y10; Y10S; Y10S436/00; Y10S436/821
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
69 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR13## R 5 , R 6 , R 7 and R 8 are hydrogen or methyl; and A is hydrogen, alkali metal or alkaline earth, with the proviso that each A is identical in the same compound.
Claim 2
Independent Claim
69 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR13## R 5 , R 6 , R 7 and R 8 are hydrogen or methyl; and A is hydrogen, alkali metal or alkaline earth, with the proviso that each A is identical in the same compound.
Claim 3
Independent Claim
68 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a pharmaceutically acceptable compound of the formula: ##STR14## R 5 , R 6 , R 7 and R 8 are hydrogen or methyl; and A is hydrogen, alkali metal or alkali earth, with the proviso that each A is identical in the same compound.
Claim 4
Independent Claim
68 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a pharmaceutically acceptable compound of the formula: ##STR14## R 5 , R 6 , R 7 and R 8 are hydrogen or methyl; and A is hydrogen, alkali metal or alkali earth, with the proviso that each A is identical in the same compound.
Claim 5
Independent Claim
48 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR15## R 5 , R 6 , R 7 and R 8 are hydrogen or methyl.
Claim 6
Independent Claim
48 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a compound of the formula: ##STR15## R 5 , R 6 , R 7 and R 8 are hydrogen or methyl.
Claim 7
Dependent Claim
14 words
A method according to claim 3 wherein the compound is 8,8'-[ureylenebis(p-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 8
Dependent Claim
14 words
A method according to claim 3 wherein the compound is 8,8'-[ureylenebis(3-methyl-p-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 9
Dependent Claim
14 words
A method according to claim 3 wherein the compound is 8,8'-[ureylenebis(m-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 10
Dependent Claim
14 words
A method according to claim 3 wherein the compound is 8,8'-[ureylenebis(4-methyl-m-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 11
Dependent Claim
14 words
A method according to claim 3 wherein the compound is 8,8'-[ureylenebis(6-methyl-m-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 12
Dependent Claim
14 words
A method according to claim 3 wherein the compound is 7,7'-[ureylenebis(m-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 13
Independent Claim
48 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a pharmaceutically acceptable compound of the formulae: ##STR16## and R 5 , R 6 , R 7 and R 8 are hydrogen or methyl.
Claim 14
Independent Claim
48 words
A method of inhibiting the complement system in a warm-blooded animal which comprises internally administering to said animal an effective complement inhibiting amount of a pharmaceutically acceptable compound of the formulae: ##STR16## and R 5 , R 6 , R 7 and R 8 are hydrogen or methyl.
Claim 15
Dependent Claim
14 words
A method according to claim 10 wherein the compound is 8,8'-[ureylenebis(p-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 16
Dependent Claim
14 words
A method according to claim 10 wherein the compound is 8,8'-[ureylenebis(3-methyl-p-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 17
Dependent Claim
14 words
A method according to claim 10 wherein the compound is 8,8'-[ureylenebis(m-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 18
Dependent Claim
14 words
A method according to claim 10 wherein the compound is 8,8'-[ureylenebis(4-methyl-m-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 19
Dependent Claim
14 words
A method according to claim 10 wherein the compound is 8,8'-[ureylenebis(6-methyl-m-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
Claim 20
Dependent Claim
14 words
A method according to claim 10 wherein the compound is 7,7'-[ureylenebis(m-phenylenecarbonylimino)]di-1,3,6-naphthalenetrisulfonic acid, hexasodium salt.
References Cited (Backward Citations)
US3897434A
Cited
US3903106A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-01 | 1981-10-31 | 1982-05-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-01 | 1985-10-31 | 1986-05-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-01 | 1989-10-31 | 1990-05-02 | $7700.00 | Window Closed / Lapsed |