2-aminocycloaliphatic amide compounds

Claim 1

A compound of the formula ##STR83## wherein the ˜ at the 1-position of the cycloaliphatic ring denotes trans-stereoconfiguration of the 1-position substituent with respect to the substituent in position 2 of the same cycloaliphatic ring; R is C 1 to C 3 -alkyl; R 1 and R 2 , taken separately, are C 1 to C 3 -alkyl, or when R 1 is C 1 to C 3 -alkyl, R 2 is C 1 to C 6 -alkyl, -CH 2 CF 3 , C 3 to C 6 -(allylic)alkenyl, C 2 to C 5 -hydroxyalkyl, C 3 to C 6 -cycloalkyl, C 3 to C 4 -cycloalkylmethyl, phenyl-C 1 to C 3 -alkyl, or R 1 and R 2 taken together with the nitrogen to which they are bonded complete a saturated, monocyclic, mononitrogen heterocyclic ring containing only carbon and nitrogen ring atoms and containing from 3 to 4 carbon atoms; said saturated monocyclic nitrogen heterocyclic rings having 3 to 4 ring carbon atoms permissively being substituted in the 3-position of the ring with hydroxy, C 1 to C 3 -alkyloxy, or C 1 to C 3 -alkanoyloxy; or N-piperazinyl ring, permissively substituted on the N'-nitrogen with a C 1 to C 3 -alkyl; R 3 is hydrogen or methyl; R 4 is hydrogen or methyl, or R 3 and R 4 can be taken together with the carbon to which they are bonded to complete a cyclopropylene ring; m is 1 to 4 and is 2 to 4 only when R 3 and R 4 are both hydrogen; n is 2 to 4; and Q is 1-naphthyl, 2-naphthyl or ##STR84## wherein each of X, Y and Z is hydrogen, a halogen having an atomic number of from 9 to 35, trifluoromethyl, C 2 to C 3 -alkyl, C 1 to C 3 -alkyloxy, azido or phenyl, and at least one of X, Y and Z is a substituent other than hydrogen, and when one of X, Y and Z is azido, phenyl, C 1 to C 3 -alkyloxy or trifluoromethyl, the remaining X, Y and Z moieties are hydrogen, and the pharmaceutically acceptable salts thereof.