Patent US4145429A successfully refreshed from Google Patents.
US4145429A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Oral veterinary preparations
Assignee: Beecham Group PLC
•
Filing: 1977-03-11
•
Granted: 1979-03-20
•
Expires: 1997-03-11
Abstract
Abstract A fluid pharmaceutical formulation for oral administration to animals comprising a medicament, an edible oil and an oleophilic clay. The oleophilic clay thickening agent is formed by replacement of inorganic cations in a natural or synthetic clay or organic cations.
Inventors
- 👤 Christopher D. Clarke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 21:57
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/02
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
77 words
In the treatment of a veterinary animal with an orally effective antibiotic, the improvement which comprises orally administering said antibiotic in veterinary fluid composition consisting essentially of from 1 to 15% w/v of an antibiotic, from 1 to 5% w/v of a natural or synthetic clay in which inorganic cations have been replaced with long chain aliphatic quaternary ammonium cations, from 0 to 2% w/v of a polar solvent and, as the balance, an edible vegetable oil.
Claim 2
Dependent Claim
77 words
In the treatment of a veterinary animal with an orally effective antibiotic, the improvement which comprises orally administering said antibiotic in veterinary fluid composition consisting essentially of from 1 to 15% w/v of an antibiotic, from 1 to 5% w/v of a natural or synthetic clay in which inorganic cations have been replaced with long chain aliphatic quaternary ammonium cations, from 0 to 2% w/v of a polar solvent and, as the balance, an edible vegetable oil.
Claim 3
Dependent Claim
67 words
The method according to claim 1 wherein said long chain aliphatic ammonium cations are of the formula: ##STR2## wherein R 1 is alkyl of 12 to 18 carbon atoms, R 2 is hydrogen, alkyl of 1 to 6 carbon atoms, benzyl or alkyl of 12 to 18 carbon atoms, and each of R 3 and R 4 are hydrogen or alkyl of 1 to 6 carbon atoms.
Claim 4
Dependent Claim
19 words
The method according to claim 2 wherein said cations are octadecylammonium, dimethyl mono- or di-octadecylammonium, dimethylhexadecylammonium or dimethylbenzyloctadecylammonium cations.
Claim 5
Dependent Claim
14 words
The method according to claim 1 wherein said clay is of the montmorillonite group.
Claim 6
Dependent Claim
23 words
The method according to claim 1 wherein said edible vegetable oil is sunflower oil, arachis oil, soyabean oil, rapeseed oil or maize oil.
Claim 7
Dependent Claim
12 words
The method according to claim 1 wherein said antibiotic is a penicillin.
Claim 8
Dependent Claim
22 words
The method according to claim 6 wherein said penicillin is cloxacillin, flucloxacillin, the 5-indanyl or phenyl ester of carbenicillin, ampicillin or amoxycillin.
Claim 9
Dependent Claim
18 words
The method according to claim 1 wherein said composition contains in addition a natural or synthetic clay absorbent.
Claim 10
Dependent Claim
11 words
The method according to claim 6 wherein said penicillin is ampicillin.
Claim 11
Dependent Claim
20 words
A method according to claim 1 wherein the composition is orally administered in the treatment of neonatal scours in piglets.
Claim 12
Dependent Claim
94 words
In the treatment of a veterinary animal with an orally effective penicillin, the improvement which comprises orally administering veterinary fluid composition consisting essentially of from 1 to 15% w/v of said penicillin, from 1 to 5% w/v of a clay of the montmorillonite group in which organic cations have been replaced by a quaternary ammonium cation of the formula: ##STR3## from about 0 to 2% of a polar solvent and, as the balance, an edible vegetable oil selected from the group consisting of sunflower oil, arachis oil, soyabean oil, rapeseed oil or maize oil.
Claim 13
Dependent Claim
94 words
In the treatment of a veterinary animal with an orally effective penicillin, the improvement which comprises orally administering veterinary fluid composition consisting essentially of from 1 to 15% w/v of said penicillin, from 1 to 5% w/v of a clay of the montmorillonite group in which organic cations have been replaced by a quaternary ammonium cation of the formula: ##STR3## from about 0 to 2% of a polar solvent and, as the balance, an edible vegetable oil selected from the group consisting of sunflower oil, arachis oil, soyabean oil, rapeseed oil or maize oil.
References Cited (Backward Citations)
US2914443A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-19 | 1982-09-18 | 1983-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-19 | 1986-09-18 | 1987-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-19 | 1990-09-18 | 1991-03-20 | $7700.00 | Window Closed / Lapsed |