Patent US4143129A successfully refreshed from Google Patents.
US4143129A
Expired / Lapsed
US
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Cephalexin tablets
Assignee: Lilly Industries Ltd
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Filing: 1978-01-16
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Granted: 1979-03-06
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Expires: 1998-01-16
Abstract
Abstract A small tablet containing over 90% by weight of an orally active cephalosporin such as cephalexin and which utilizes as a binder polyvinyl pyrrolidone having a number average molecular weight of from 500,000 to 1,500,000.
Inventors
- 👤 Richard Marsden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 08:48
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61K31/542; A61K31/545; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
136 words
A pharmaceutical tablet comprised of: (a) from about 90% to about 96 percent by weight of orally active cephalexin; (b) from about 4 to about 10 percent by weight of excipients comprising: (i) from about 2 to about 5 percent by weight of polyvinyl pyrrolidone having an average molecular weight of from about 500,000 to about 1,500,000; (ii) from about 1.5 to about 5 percent by weight of a disintegrant selected from the group consisting of sodium starch glycolate, sodium carboxymethylcellulose, and a weakly acidic methacrylic acid-divinylbenzene copolymer zeolite; and (iii) from about 0.3 to about 2 percent by weight of a pharmaceutically acceptable lubricant, and having (c) a diametral crushing strength of from about 5.0 to about 15.0 Kg; and (d) a disintegration time in distilled water of 15 minutes or less at 37° C.
Claim 2
Dependent Claim
136 words
A pharmaceutical tablet comprised of: (a) from about 90% to about 96 percent by weight of orally active cephalexin; (b) from about 4 to about 10 percent by weight of excipients comprising: (i) from about 2 to about 5 percent by weight of polyvinyl pyrrolidone having an average molecular weight of from about 500,000 to about 1,500,000; (ii) from about 1.5 to about 5 percent by weight of a disintegrant selected from the group consisting of sodium starch glycolate, sodium carboxymethylcellulose, and a weakly acidic methacrylic acid-divinylbenzene copolymer zeolite; and (iii) from about 0.3 to about 2 percent by weight of a pharmaceutically acceptable lubricant, and having (c) a diametral crushing strength of from about 5.0 to about 15.0 Kg; and (d) a disintegration time in distilled water of 15 minutes or less at 37° C.
Claim 3
Dependent Claim
15 words
A tablet according to claim 1 wherein the orally active cephalexin is 7-(D-α-amino-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid, monohydrate.
Claim 4
Dependent Claim
29 words
A tablet according to claim 1 wherein the disintegrant is a sodium starch glycolate containing from 15 to 35, most preferably about 25, carboxymethyl groups per 100 glucose units.
Claim 5
Dependent Claim
33 words
A tablet according to claim 1 which contains approximately 1000 mg. of cephalexin and which has a volume of from about 0.80 to about 0.95 ml., when determined by displacement of liquid paraffin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-05 | 1982-09-04 | 1983-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-05 | 1986-09-04 | 1987-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-05 | 1990-09-04 | 1991-03-06 | $7700.00 | Window Closed / Lapsed |