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US4140762A
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Influenza sub-unit vaccine
Assignee: Sandoz AG
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Filing: 1977-09-23
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Granted: 1979-02-20
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Expires: 1997-09-23
Abstract
Abstract This invention provides a novel sub-unit vaccine comprising a mixture of the hemagglutinin and neuraminidase components of the virus in the substantial absence of non-essential viral particles.
Inventors
- 👤 Helmut Bachmayer
- 👤 Gerhard Schmidt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:19
CPC Classifications
C; C12; C12N; C12N7/00; A; A61; A61K; A61K39/00; A61K39/12; A61K39/145; A61K2039/51; A61K2039/525; A61K2039/5252; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16111; C12N2760/16134; C12N2760/16161; C12N2760/16163; C12N2760/16211; C12N2760/16234
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
38 words
An influenza vaccine comprising an effective amount of a mixture of the hemagglutinin and neuraminidase components of influenza virus in the substantial absence of other components of the influenza viral particle, in association with an inert liquid diluent.
Claim 2
Dependent Claim
38 words
An influenza vaccine comprising an effective amount of a mixture of the hemagglutinin and neuraminidase components of influenza virus in the substantial absence of other components of the influenza viral particle, in association with an inert liquid diluent.
Claim 3
Dependent Claim
49 words
A vaccine according to claim 1, in which the mixture of hemagglutinin and neuraminidase components is produced by a method which comprises treating influenza virus in an aqueous medium with a cationic detergent to selectively solubilise such components and separating the resulting solubilised components from the residual subviral particles.
Claim 4
Dependent Claim
28 words
A vaccine according to claim 2, which contains from 600 to 3000 international units of the mixture of hemagglutinin and neuraminidase components per 0.5 ml of the vaccine.
Claim 5
Dependent Claim
13 words
A vaccine according to claim 3, in which the diluent comprises physiological saline.
Claim 6
Dependent Claim
15 words
A vaccine according to claim 4, in which the diluent comprises phosphate buffered physiological saline.
Claim 7
Dependent Claim
13 words
A vaccine according to claim 3, additionally comprising a preserving or inactivating agent.
Claim 8
Dependent Claim
13 words
A vaccine according to claim 6, in which the inactivating agents is formaldehyde.
Claim 9
Dependent Claim
11 words
A vaccine according to claim 3, additionally comprising an immunological adjuvant.
Claim 10
Dependent Claim
13 words
A vaccine according to claim 8, in which the adjuvant comprises aluminium hydroxide.
Claim 11
Dependent Claim
21 words
A method of inducing immunity against influenza virus, comprising administering an immunologically effective amount of a vaccine according to claim 2.
References Cited (Backward Citations)
US4009258A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |